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Characterization of molecularly imprinted polymer nanoparticles by photon correlation spectroscopy

Malm, Bjoern; Yoshimatsu, Keiichi LU ; Ye, Lei LU and Krozer, Anatol (2014) In Journal of Molecular Recognition 27(12). p.714-721
Abstract
We follow template-binding induced aggregation of nanoparticles enantioselectively imprinted against (S)-propranolol, and the non-imprinted ones, using photon correlation spectroscopy (dynamic light scattering). The method requires no separation steps. We have characterized binding of (R,S)-propranolol to the imprinted polymers and determined the degree of non-specificity by comparing the specific binding with the results obtained using non-imprinted nanoparticles. Using (S)-propranolol as a template for binding to (S)-imprinted nanoparticle, and (R)-propranolol as a non-specific control, we have determined range of concentrations where chiral recognition can be observed. By studying aggregation induced by three analytes related to... (More)
We follow template-binding induced aggregation of nanoparticles enantioselectively imprinted against (S)-propranolol, and the non-imprinted ones, using photon correlation spectroscopy (dynamic light scattering). The method requires no separation steps. We have characterized binding of (R,S)-propranolol to the imprinted polymers and determined the degree of non-specificity by comparing the specific binding with the results obtained using non-imprinted nanoparticles. Using (S)-propranolol as a template for binding to (S)-imprinted nanoparticle, and (R)-propranolol as a non-specific control, we have determined range of concentrations where chiral recognition can be observed. By studying aggregation induced by three analytes related to propranolol, atenolol, betaxolol, and 1-amino-3-(naphthalen-1-yloxy)propan-2-ol, we were able to determine which parts of the template are involved in the specific binding, discuss several details of specific adsorption, and the structure of the imprinted site. Copyright (c) 2014 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
molecularly imprinted polymers, Brownian motion, chiral selectivity, aggregation kinetics, colloidal suspension
in
Journal of Molecular Recognition
volume
27
issue
12
pages
714 - 721
publisher
John Wiley & Sons
external identifiers
  • wos:000343997400004
  • scopus:84927138481
ISSN
1099-1352
DOI
10.1002/jmr.2397
language
English
LU publication?
yes
id
d517e5d9-d28c-4d2a-8197-4b16fc364963 (old id 4874895)
date added to LUP
2015-01-07 09:37:15
date last changed
2017-01-01 03:46:21
@article{d517e5d9-d28c-4d2a-8197-4b16fc364963,
  abstract     = {We follow template-binding induced aggregation of nanoparticles enantioselectively imprinted against (S)-propranolol, and the non-imprinted ones, using photon correlation spectroscopy (dynamic light scattering). The method requires no separation steps. We have characterized binding of (R,S)-propranolol to the imprinted polymers and determined the degree of non-specificity by comparing the specific binding with the results obtained using non-imprinted nanoparticles. Using (S)-propranolol as a template for binding to (S)-imprinted nanoparticle, and (R)-propranolol as a non-specific control, we have determined range of concentrations where chiral recognition can be observed. By studying aggregation induced by three analytes related to propranolol, atenolol, betaxolol, and 1-amino-3-(naphthalen-1-yloxy)propan-2-ol, we were able to determine which parts of the template are involved in the specific binding, discuss several details of specific adsorption, and the structure of the imprinted site. Copyright (c) 2014 John Wiley & Sons, Ltd.},
  author       = {Malm, Bjoern and Yoshimatsu, Keiichi and Ye, Lei and Krozer, Anatol},
  issn         = {1099-1352},
  keyword      = {molecularly imprinted polymers,Brownian motion,chiral selectivity,aggregation kinetics,colloidal suspension},
  language     = {eng},
  number       = {12},
  pages        = {714--721},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Molecular Recognition},
  title        = {Characterization of molecularly imprinted polymer nanoparticles by photon correlation spectroscopy},
  url          = {http://dx.doi.org/10.1002/jmr.2397},
  volume       = {27},
  year         = {2014},
}