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A quantitative review of MHC-based mating preference: the role of diversity and dissimilarity

Kamiya, T.; O'Dwyer, K.; Westerdahl, Helena LU ; Senior, A. and Nakagawa, S. (2014) In Molecular Ecology 23(21). p.5151-5163
Abstract
Sexual selection hypotheses stipulate that the major histocompatibility complex genes (MHC) constitute a key molecular underpinning for mate choice in vertebrates. The last four decades saw growing empirical literature on the role of MHC diversity and dissimilarity in mate choice for a wide range of vertebrate animals, but with mixed support for its significance in natural populations. Using formal phylogenetic meta-analysis and meta-regression techniques, we quantitatively review the existing literature on MHC-dependent mating preferences in nonhuman vertebrates with a focus on the role of MHC diversity and dissimilarity. Overall, we found small, statistically nonsignificant, average effect sizes for both diversity- and... (More)
Sexual selection hypotheses stipulate that the major histocompatibility complex genes (MHC) constitute a key molecular underpinning for mate choice in vertebrates. The last four decades saw growing empirical literature on the role of MHC diversity and dissimilarity in mate choice for a wide range of vertebrate animals, but with mixed support for its significance in natural populations. Using formal phylogenetic meta-analysis and meta-regression techniques, we quantitatively review the existing literature on MHC-dependent mating preferences in nonhuman vertebrates with a focus on the role of MHC diversity and dissimilarity. Overall, we found small, statistically nonsignificant, average effect sizes for both diversity- and dissimilarity-based mate choice (r=0.113 and 0.064, respectively). Importantly, however, meta-regression models revealed statistically significant support regarding female choice for diversity, and choice for dissimilarity (regardless of choosy sex) only when dissimilarity is characterized across multiple loci. Little difference was found among vertebrate taxa; however, the lack of statistical power meant statistically significant effects were limited to some taxa. We found little sign of publication bias; thus, our results are likely to be robust. In light of our quantitative assessment, methodological improvements and fruitful future avenues of research are highlighted. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
genetic compatibility, mate choice, meta-analysis, meta-regression, MHC, diversity, the major histocompatibility complex
in
Molecular Ecology
volume
23
issue
21
pages
5151 - 5163
publisher
Wiley-Blackwell
external identifiers
  • wos:000344374000004
  • scopus:84911805861
ISSN
0962-1083
DOI
10.1111/mec.12934
project
Avian MHC genes
language
English
LU publication?
yes
id
68aaae67-5653-4d01-9c63-6bc13d5180f1 (old id 4875102)
date added to LUP
2014-12-30 14:49:01
date last changed
2017-11-19 03:04:15
@article{68aaae67-5653-4d01-9c63-6bc13d5180f1,
  abstract     = {Sexual selection hypotheses stipulate that the major histocompatibility complex genes (MHC) constitute a key molecular underpinning for mate choice in vertebrates. The last four decades saw growing empirical literature on the role of MHC diversity and dissimilarity in mate choice for a wide range of vertebrate animals, but with mixed support for its significance in natural populations. Using formal phylogenetic meta-analysis and meta-regression techniques, we quantitatively review the existing literature on MHC-dependent mating preferences in nonhuman vertebrates with a focus on the role of MHC diversity and dissimilarity. Overall, we found small, statistically nonsignificant, average effect sizes for both diversity- and dissimilarity-based mate choice (r=0.113 and 0.064, respectively). Importantly, however, meta-regression models revealed statistically significant support regarding female choice for diversity, and choice for dissimilarity (regardless of choosy sex) only when dissimilarity is characterized across multiple loci. Little difference was found among vertebrate taxa; however, the lack of statistical power meant statistically significant effects were limited to some taxa. We found little sign of publication bias; thus, our results are likely to be robust. In light of our quantitative assessment, methodological improvements and fruitful future avenues of research are highlighted.},
  author       = {Kamiya, T. and O'Dwyer, K. and Westerdahl, Helena and Senior, A. and Nakagawa, S.},
  issn         = {0962-1083},
  keyword      = {genetic compatibility,mate choice,meta-analysis,meta-regression,MHC,diversity,the major histocompatibility complex},
  language     = {eng},
  number       = {21},
  pages        = {5151--5163},
  publisher    = {Wiley-Blackwell},
  series       = {Molecular Ecology},
  title        = {A quantitative review of MHC-based mating preference: the role of diversity and dissimilarity},
  url          = {http://dx.doi.org/10.1111/mec.12934},
  volume       = {23},
  year         = {2014},
}