Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II : the EDEN Fragrance Study
(2021) In Journal of the European Academy of Dermatology and Venereology 35(8). p.1692-1701- Abstract
Background: In a European study on contact allergy in the general population, it has been hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure and thereafter subsequent avoidance of scented products implied a diagnosis of allergic contact dermatitis. Objectives: The primary aim of this study was to validate this hypothesis/algorithm. The secondary aim was to investigate whether there was any association between the outcome of the recent repeated open application test (ROAT) and the patch test reactivity. Methods: One hundred nine subjects with and without contact allergy to fragrance mix II (FM II) were recruited. Volunteers from six European dermatology clinics... (More)
Background: In a European study on contact allergy in the general population, it has been hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure and thereafter subsequent avoidance of scented products implied a diagnosis of allergic contact dermatitis. Objectives: The primary aim of this study was to validate this hypothesis/algorithm. The secondary aim was to investigate whether there was any association between the outcome of the recent repeated open application test (ROAT) and the patch test reactivity. Methods: One hundred nine subjects with and without contact allergy to fragrance mix II (FM II) were recruited. Volunteers from six European dermatology clinics participated in the study including a patch test and a ROAT. Results: Twenty-four positive ROAT reactions were noted in total including 20 of those 32 with contact allergy to FM II. None of the volunteers reacted to the vehicle (P < 0.001). More individuals with a positive algorithm had positive ROATs when compared with those with a negative algorithm. However, the difference was not statistically significant (P = 0.12). The lower the patch test concentration eliciting a positive test reaction, the more likely was a positive ROAT and the more likely that the positive ROAT appeared early during the investigative period. Conclusions: The algorithm used in this study was not validated but it was indicated in this ROAT setup. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application period.
(Less)
- author
- Bruze, M. LU ; Engfeldt, M. LU ; Elsner, P. ; Gonçalo, M. ; Naldi, L. ; Schuttelaar, M. L.A. ; Svedman, C. LU ; Svensson LU and Ofenloch, R.
- organization
- publishing date
- 2021-04-29
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the European Academy of Dermatology and Venereology
- volume
- 35
- issue
- 8
- pages
- 1692 - 1701
- publisher
- Elsevier
- external identifiers
-
- scopus:85105717883
- pmid:33914959
- ISSN
- 0926-9959
- DOI
- 10.1111/jdv.17315
- language
- English
- LU publication?
- yes
- id
- 487a49c1-043e-40fe-97a6-7e5a433ce97a
- date added to LUP
- 2021-06-01 22:30:34
- date last changed
- 2024-11-03 02:28:26
@article{487a49c1-043e-40fe-97a6-7e5a433ce97a,
abstract = {{<p>Background: In a European study on contact allergy in the general population, it has been hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure and thereafter subsequent avoidance of scented products implied a diagnosis of allergic contact dermatitis. Objectives: The primary aim of this study was to validate this hypothesis/algorithm. The secondary aim was to investigate whether there was any association between the outcome of the recent repeated open application test (ROAT) and the patch test reactivity. Methods: One hundred nine subjects with and without contact allergy to fragrance mix II (FM II) were recruited. Volunteers from six European dermatology clinics participated in the study including a patch test and a ROAT. Results: Twenty-four positive ROAT reactions were noted in total including 20 of those 32 with contact allergy to FM II. None of the volunteers reacted to the vehicle (P < 0.001). More individuals with a positive algorithm had positive ROATs when compared with those with a negative algorithm. However, the difference was not statistically significant (P = 0.12). The lower the patch test concentration eliciting a positive test reaction, the more likely was a positive ROAT and the more likely that the positive ROAT appeared early during the investigative period. Conclusions: The algorithm used in this study was not validated but it was indicated in this ROAT setup. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application period.</p>}},
author = {{Bruze, M. and Engfeldt, M. and Elsner, P. and Gonçalo, M. and Naldi, L. and Schuttelaar, M. L.A. and Svedman, C. and Svensson and Ofenloch, R.}},
issn = {{0926-9959}},
language = {{eng}},
month = {{04}},
number = {{8}},
pages = {{1692--1701}},
publisher = {{Elsevier}},
series = {{Journal of the European Academy of Dermatology and Venereology}},
title = {{Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II : the EDEN Fragrance Study}},
url = {{http://dx.doi.org/10.1111/jdv.17315}},
doi = {{10.1111/jdv.17315}},
volume = {{35}},
year = {{2021}},
}