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Optimization of disintegration time and crushing strength of a tablet formulation

Lindberg, N.-O.; Jönsson, C. and Holmquist, Björn LU (1985) In Drug Development and Industrial Pharmacy 11(4). p.931-944
Abstract
In an experiment with a factorial design, the following aspects were scrutinized: the impact on disintegration time and crushing strength caused by the loss-on-drying of the granulation; the granule-size distribution; the lubricant concentration; the compression force; and the pre-compression. Both with regard to disintegration time and crushing strength, these factors were found to have a significant influence: the loss-on-drying of the granulation; the fraction less than 0.150 mm; the concentration of magnesium stearate; and the compression force. A reduction of the tablet disintegration time was obtained by means of an increase of the granulation moisture; by an increase of the fine fraction; or by a reduction of the lubricant... (More)
In an experiment with a factorial design, the following aspects were scrutinized: the impact on disintegration time and crushing strength caused by the loss-on-drying of the granulation; the granule-size distribution; the lubricant concentration; the compression force; and the pre-compression. Both with regard to disintegration time and crushing strength, these factors were found to have a significant influence: the loss-on-drying of the granulation; the fraction less than 0.150 mm; the concentration of magnesium stearate; and the compression force. A reduction of the tablet disintegration time was obtained by means of an increase of the granulation moisture; by an increase of the fine fraction; or by a reduction of the lubricant concentration or the compression force. The tablet crushing strength was increased by reducing the deviation of the granulation loss-on-drying from approximately 4.6 %; by a reduction of the fine fraction; by decreasing the lubricant concentration; or by increasing the compression force. The fraction larger than 0.300 mm had no significant influence; nor did the pre-compression. Further, there were no significant interactions.



By means of superimposing contour plots of disintegration time and crushing strength, a region was obtained where the requirements of disintegration time and crushing strength could be satisfied by controlling the processing variables. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Development and Industrial Pharmacy
volume
11
issue
4
pages
931 - 944
publisher
Marcel Dekker
external identifiers
  • scopus:0021888210
ISSN
0363-9045
DOI
10.3109/03639048509057467
language
English
LU publication?
yes
id
df0364b6-c0c2-4e0a-ab94-bc303df65612 (old id 4897268)
date added to LUP
2015-01-12 10:05:00
date last changed
2017-01-01 05:16:55
@article{df0364b6-c0c2-4e0a-ab94-bc303df65612,
  abstract     = {In an experiment with a factorial design, the following aspects were scrutinized: the impact on disintegration time and crushing strength caused by the loss-on-drying of the granulation; the granule-size distribution; the lubricant concentration; the compression force; and the pre-compression. Both with regard to disintegration time and crushing strength, these factors were found to have a significant influence: the loss-on-drying of the granulation; the fraction less than 0.150 mm; the concentration of magnesium stearate; and the compression force. A reduction of the tablet disintegration time was obtained by means of an increase of the granulation moisture; by an increase of the fine fraction; or by a reduction of the lubricant concentration or the compression force. The tablet crushing strength was increased by reducing the deviation of the granulation loss-on-drying from approximately 4.6 %; by a reduction of the fine fraction; by decreasing the lubricant concentration; or by increasing the compression force. The fraction larger than 0.300 mm had no significant influence; nor did the pre-compression. Further, there were no significant interactions.<br/><br>
<br/><br>
By means of superimposing contour plots of disintegration time and crushing strength, a region was obtained where the requirements of disintegration time and crushing strength could be satisfied by controlling the processing variables.},
  author       = {Lindberg, N.-O. and Jönsson, C. and Holmquist, Björn},
  issn         = {0363-9045},
  language     = {eng},
  number       = {4},
  pages        = {931--944},
  publisher    = {Marcel Dekker},
  series       = {Drug Development and Industrial Pharmacy},
  title        = {Optimization of disintegration time and crushing strength of a tablet formulation},
  url          = {http://dx.doi.org/10.3109/03639048509057467},
  volume       = {11},
  year         = {1985},
}