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The granulation of a tablet formulation in a high-speed mixer, Diosna P 25

Lindberg, N.-O.; Jönsson, C. and Holmquist, Björn LU (1985) In Drug Development and Industrial Pharmacy 11(4). p.917-930
Abstract
The impeller speed, the loss-on-drying of starch, and the added amount of water significantly influenced these response variables: granule fractions of less than 0.150 mm and more than 2.00 mm; and granule median diameter. The influence of the drug concentration on the response variables was less important. All the response variables showed significant interactions.



At a fixed impeller speed, the fine fraction was reduced when the loss-on-drying of starch increased, and when water was added in increasing amounts. The coarse fraction and granule median diameter increased along with an increasing moisture content in the starch. Increasing amounts of added water had the same effect.



The response surface... (More)
The impeller speed, the loss-on-drying of starch, and the added amount of water significantly influenced these response variables: granule fractions of less than 0.150 mm and more than 2.00 mm; and granule median diameter. The influence of the drug concentration on the response variables was less important. All the response variables showed significant interactions.



At a fixed impeller speed, the fine fraction was reduced when the loss-on-drying of starch increased, and when water was added in increasing amounts. The coarse fraction and granule median diameter increased along with an increasing moisture content in the starch. Increasing amounts of added water had the same effect.



The response surface contours of a fraction less than 0.150 mm, and a fraction exceeding 2.00 mm, were plotted. So was the granule median diameter. Suitable levels for the processing variables involved in obtaining a granulation of the desired proportions - fine or coarse fraction - can be read from the contour plots.



Heat was generated in the mixer during kneading, which caused some evaporation of water.



The change in the rotation rate of the impeller during the addition of the granulating liquid can be used as an indication of the fraction percentages below 0.150 mm and above 2.00 mm, but not of the median diameter. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Development and Industrial Pharmacy
volume
11
issue
4
pages
917 - 930
publisher
Marcel Dekker
external identifiers
  • scopus:0021807434
ISSN
0363-9045
DOI
10.3109/03639048509057466
language
English
LU publication?
yes
id
24015cea-9ff3-43fb-8553-17ac721d0d42 (old id 4897271)
date added to LUP
2015-01-12 08:56:14
date last changed
2017-03-05 03:38:06
@article{24015cea-9ff3-43fb-8553-17ac721d0d42,
  abstract     = {The impeller speed, the loss-on-drying of starch, and the added amount of water significantly influenced these response variables: granule fractions of less than 0.150 mm and more than 2.00 mm; and granule median diameter. The influence of the drug concentration on the response variables was less important. All the response variables showed significant interactions.<br/><br>
<br/><br>
At a fixed impeller speed, the fine fraction was reduced when the loss-on-drying of starch increased, and when water was added in increasing amounts. The coarse fraction and granule median diameter increased along with an increasing moisture content in the starch. Increasing amounts of added water had the same effect.<br/><br>
<br/><br>
The response surface contours of a fraction less than 0.150 mm, and a fraction exceeding 2.00 mm, were plotted. So was the granule median diameter. Suitable levels for the processing variables involved in obtaining a granulation of the desired proportions - fine or coarse fraction - can be read from the contour plots.<br/><br>
<br/><br>
Heat was generated in the mixer during kneading, which caused some evaporation of water.<br/><br>
<br/><br>
The change in the rotation rate of the impeller during the addition of the granulating liquid can be used as an indication of the fraction percentages below 0.150 mm and above 2.00 mm, but not of the median diameter.},
  author       = {Lindberg, N.-O. and Jönsson, C. and Holmquist, Björn},
  issn         = {0363-9045},
  language     = {eng},
  number       = {4},
  pages        = {917--930},
  publisher    = {Marcel Dekker},
  series       = {Drug Development and Industrial Pharmacy},
  title        = {The granulation of a tablet formulation in a high-speed mixer, Diosna P 25},
  url          = {http://dx.doi.org/10.3109/03639048509057466},
  volume       = {11},
  year         = {1985},
}