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Exploring the diabetic kidney proteome : A junction of tissue and serum

Liljedahl, Leena LU (2016)
Abstract (Swedish)
Diabetic kidney disease is one of the major complications associated with diabetes. Approximately 25-40% of both type 1 and type 2 diabetes patients will acquire a kidney complication and despite global efforts to reduce the prevalence of diabetic kidney disease, it is a leading cause of kidney failure in the western world. There are few treatment options directly targeting the kidney.
The overall aim of this thesis was to dig past the current state of knowledge and delve deeper into the proteomic profile of diabetic kidney disease. By the use of discovery based and targeted mass spectrometry, the kidney proteomes of two diabetic mouse models reflecting type 1 and type 2 diabetes with early kidney disease were investigated and the... (More)
Diabetic kidney disease is one of the major complications associated with diabetes. Approximately 25-40% of both type 1 and type 2 diabetes patients will acquire a kidney complication and despite global efforts to reduce the prevalence of diabetic kidney disease, it is a leading cause of kidney failure in the western world. There are few treatment options directly targeting the kidney.
The overall aim of this thesis was to dig past the current state of knowledge and delve deeper into the proteomic profile of diabetic kidney disease. By the use of discovery based and targeted mass spectrometry, the kidney proteomes of two diabetic mouse models reflecting type 1 and type 2 diabetes with early kidney disease were investigated and the serum proteomes of diabetes patients with various degrees of albuminuria were compared.
In summary, the majority of the changes were seen for proteins with expression in the tubules, the reabsorbing organ in the kidneys and not in the glomeruli, which is the filtering unit. The findings in this thesis could imply that we need to re-think the target of kidney medication and the importance of tubuloglomerular feedback.
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Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Jean-Charles Sanchez, University of Geneva, Switzerland
organization
publishing date
type
Thesis
publication status
published
subject
edition
1
pages
150 pages
publisher
Department of Immunotechnology, Lund University
defense location
lecture hall Hörsalen, Medicon Village, Scheelevägen 2, Lund University, Faculty of Engineering LTH, Lund
defense date
2017-01-13 09:15
ISBN
978-91-7753-112-8
978-91-7753-113-5
language
English
LU publication?
yes
id
48985609-0c8c-43c9-8278-1a7574285cd0
date added to LUP
2016-12-15 16:14:14
date last changed
2016-12-21 08:15:17
@phdthesis{48985609-0c8c-43c9-8278-1a7574285cd0,
  abstract     = {Diabetic kidney disease is one of the major complications associated with diabetes. Approximately 25-40% of both type 1 and type 2 diabetes patients will acquire a kidney complication and despite global efforts to reduce the prevalence of diabetic kidney disease, it is a leading cause of kidney failure in the western world. There are few treatment options directly targeting the kidney.<br/>The overall aim of this thesis was to dig past the current state of knowledge and delve deeper into the proteomic profile of diabetic kidney disease. By the use of discovery based and targeted mass spectrometry, the kidney proteomes of two diabetic mouse models reflecting type 1 and type 2 diabetes with early kidney disease were investigated and the serum proteomes of diabetes patients with various degrees of albuminuria were compared. <br/>In summary, the majority of the changes were seen for proteins with expression in the tubules, the reabsorbing organ in the kidneys and not in the glomeruli, which is the filtering unit. The findings in this thesis could imply that we need to re-think the target of kidney medication and the importance of tubuloglomerular feedback.<br/>},
  author       = {Liljedahl, Leena},
  isbn         = {978-91-7753-112-8},
  language     = {eng},
  month        = {12},
  pages        = {150},
  publisher    = {Department of Immunotechnology, Lund University},
  school       = {Lund University},
  title        = {Exploring the diabetic kidney proteome : A junction of tissue and serum},
  year         = {2016},
}