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Drugs affecting glycosaminoglycan metabolism

Ghiselli, Giancarlo LU and Maccarana, Marco LU (2016) In Drug Discovery Today 21(7). p.1162-1169
Abstract

Glycosaminoglycans (GAGs) are charged polysaccharides ubiquitously present at the cell surface and in the extracellular matrix. GAGs are crucial for cellular homeostasis, and their metabolism is altered during pathological processes. However, little consideration has been given to the regulation of the GAG milieu through pharmacological interventions. In this review, we provide a classification of small molecules affecting GAG metabolism based on their mechanism of action. Furthermore, we present evidence to show that clinically approved drugs affect GAG metabolism and that this could contribute to their therapeutic benefit.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Discovery Today
volume
21
issue
7
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:84974577579
  • wos:000379105000012
ISSN
1359-6446
DOI
10.1016/j.drudis.2016.05.010
language
English
LU publication?
yes
id
48a2f28e-02f4-4c68-ab2c-f5a6fd66e93b
date added to LUP
2017-01-17 09:31:24
date last changed
2017-09-18 11:32:04
@article{48a2f28e-02f4-4c68-ab2c-f5a6fd66e93b,
  abstract     = {<p>Glycosaminoglycans (GAGs) are charged polysaccharides ubiquitously present at the cell surface and in the extracellular matrix. GAGs are crucial for cellular homeostasis, and their metabolism is altered during pathological processes. However, little consideration has been given to the regulation of the GAG milieu through pharmacological interventions. In this review, we provide a classification of small molecules affecting GAG metabolism based on their mechanism of action. Furthermore, we present evidence to show that clinically approved drugs affect GAG metabolism and that this could contribute to their therapeutic benefit.</p>},
  author       = {Ghiselli, Giancarlo and Maccarana, Marco},
  issn         = {1359-6446},
  language     = {eng},
  month        = {07},
  number       = {7},
  pages        = {1162--1169},
  publisher    = {Elsevier},
  series       = {Drug Discovery Today},
  title        = {Drugs affecting glycosaminoglycan metabolism},
  url          = {http://dx.doi.org/10.1016/j.drudis.2016.05.010},
  volume       = {21},
  year         = {2016},
}