Drugs affecting glycosaminoglycan metabolism
(2016) In Drug Discovery Today 21(7). p.1162-1169- Abstract
Glycosaminoglycans (GAGs) are charged polysaccharides ubiquitously present at the cell surface and in the extracellular matrix. GAGs are crucial for cellular homeostasis, and their metabolism is altered during pathological processes. However, little consideration has been given to the regulation of the GAG milieu through pharmacological interventions. In this review, we provide a classification of small molecules affecting GAG metabolism based on their mechanism of action. Furthermore, we present evidence to show that clinically approved drugs affect GAG metabolism and that this could contribute to their therapeutic benefit.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/48a2f28e-02f4-4c68-ab2c-f5a6fd66e93b
- author
- Ghiselli, Giancarlo LU and Maccarana, Marco LU
- organization
- publishing date
- 2016-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Discovery Today
- volume
- 21
- issue
- 7
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84974577579
- pmid:27217160
- wos:000379105000012
- ISSN
- 1359-6446
- DOI
- 10.1016/j.drudis.2016.05.010
- language
- English
- LU publication?
- yes
- id
- 48a2f28e-02f4-4c68-ab2c-f5a6fd66e93b
- date added to LUP
- 2017-01-17 09:31:24
- date last changed
- 2025-01-12 19:35:59
@article{48a2f28e-02f4-4c68-ab2c-f5a6fd66e93b, abstract = {{<p>Glycosaminoglycans (GAGs) are charged polysaccharides ubiquitously present at the cell surface and in the extracellular matrix. GAGs are crucial for cellular homeostasis, and their metabolism is altered during pathological processes. However, little consideration has been given to the regulation of the GAG milieu through pharmacological interventions. In this review, we provide a classification of small molecules affecting GAG metabolism based on their mechanism of action. Furthermore, we present evidence to show that clinically approved drugs affect GAG metabolism and that this could contribute to their therapeutic benefit.</p>}}, author = {{Ghiselli, Giancarlo and Maccarana, Marco}}, issn = {{1359-6446}}, language = {{eng}}, month = {{07}}, number = {{7}}, pages = {{1162--1169}}, publisher = {{Elsevier}}, series = {{Drug Discovery Today}}, title = {{Drugs affecting glycosaminoglycan metabolism}}, url = {{http://dx.doi.org/10.1016/j.drudis.2016.05.010}}, doi = {{10.1016/j.drudis.2016.05.010}}, volume = {{21}}, year = {{2016}}, }