Infiltration of Mast Cells in Rat Colon Is a Consequence of Ischemia/Reperfusion.
(2008) In Digestive Diseases and Sciences 53. p.3158-3169- Abstract
- Intestinal ischemia as well as mastocytosis occur in patients with inflammatory bowel disease and irritable bowel syndrome. Our aim was to clarify how ischemia with reperfusion (I/R) affects the structure, enteric neurons, and immune cells in the colon. Rats were subjected to colon ischemia for 1 h and reperfused for 1 day up to 20 weeks; sham-operated rats were used as controls. No structural remodeling of the intestinal segment was detected after I/R. The number and distribution of eosinophils were not affected by I/R. Local areas containing numerous mast cells were detected in the muscle layers, the serosa, and in and around the myenteric ganglia 4-20 weeks post ischemia. It was notable that myenteric ganglionic formations within... (More)
- Intestinal ischemia as well as mastocytosis occur in patients with inflammatory bowel disease and irritable bowel syndrome. Our aim was to clarify how ischemia with reperfusion (I/R) affects the structure, enteric neurons, and immune cells in the colon. Rats were subjected to colon ischemia for 1 h and reperfused for 1 day up to 20 weeks; sham-operated rats were used as controls. No structural remodeling of the intestinal segment was detected after I/R. The number and distribution of eosinophils were not affected by I/R. Local areas containing numerous mast cells were detected in the muscle layers, the serosa, and in and around the myenteric ganglia 4-20 weeks post ischemia. It was notable that myenteric ganglionic formations within mast-cell-rich areas virtually lacked neurons. Mast cells were rarely found in controls. In conclusion, I/R of the colon attracts mast cells, and death of myenteric neurons occurs in such locations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1154433
- author
- Sand, Elin ; Themner-Persson, Anna LU and Ekblad, Eva LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Digestive Diseases and Sciences
- volume
- 53
- pages
- 3158 - 3169
- publisher
- Springer
- external identifiers
-
- wos:000260837000016
- pmid:18463982
- scopus:55949100162
- pmid:18463982
- ISSN
- 1573-2568
- DOI
- 10.1007/s10620-008-0279-x
- language
- English
- LU publication?
- yes
- id
- 48a470f0-3dd6-47ce-a9c3-ccee79120171 (old id 1154433)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18463982?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:49
- date last changed
- 2022-04-15 21:18:12
@article{48a470f0-3dd6-47ce-a9c3-ccee79120171,
abstract = {{Intestinal ischemia as well as mastocytosis occur in patients with inflammatory bowel disease and irritable bowel syndrome. Our aim was to clarify how ischemia with reperfusion (I/R) affects the structure, enteric neurons, and immune cells in the colon. Rats were subjected to colon ischemia for 1 h and reperfused for 1 day up to 20 weeks; sham-operated rats were used as controls. No structural remodeling of the intestinal segment was detected after I/R. The number and distribution of eosinophils were not affected by I/R. Local areas containing numerous mast cells were detected in the muscle layers, the serosa, and in and around the myenteric ganglia 4-20 weeks post ischemia. It was notable that myenteric ganglionic formations within mast-cell-rich areas virtually lacked neurons. Mast cells were rarely found in controls. In conclusion, I/R of the colon attracts mast cells, and death of myenteric neurons occurs in such locations.}},
author = {{Sand, Elin and Themner-Persson, Anna and Ekblad, Eva}},
issn = {{1573-2568}},
language = {{eng}},
pages = {{3158--3169}},
publisher = {{Springer}},
series = {{Digestive Diseases and Sciences}},
title = {{Infiltration of Mast Cells in Rat Colon Is a Consequence of Ischemia/Reperfusion.}},
url = {{http://dx.doi.org/10.1007/s10620-008-0279-x}},
doi = {{10.1007/s10620-008-0279-x}},
volume = {{53}},
year = {{2008}},
}