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PSA : role in screening and monitoring patients with prostate cancer

Carlsson, Sigrid V. LU ; Murata, Kazunori ; Danila, Daniel C. and Lilja, Hans LU orcid (2022) p.131-172
Abstract

The test used for early detection and monitoring of prostate cancer—prostate-specific antigen (PSA)—is one of the most accurate and frequently used tumor markers in medicine today. No tumor marker has had such a critical impact on early detection through stage-migration, and monitoring after treatment for prostate cancer as the blood test PSA. This chapter provides an overview of the PSA test and its distinct molecular forms in blood, in screening, early detection and monitoring of prostate cancer. This chapter gives a summary of the randomized controlled trials of PSA-screening and recommendations from national guidelines groups. The chapter discusses the role of the PSA-test as a tool to discriminate clinically significant from... (More)

The test used for early detection and monitoring of prostate cancer—prostate-specific antigen (PSA)—is one of the most accurate and frequently used tumor markers in medicine today. No tumor marker has had such a critical impact on early detection through stage-migration, and monitoring after treatment for prostate cancer as the blood test PSA. This chapter provides an overview of the PSA test and its distinct molecular forms in blood, in screening, early detection and monitoring of prostate cancer. This chapter gives a summary of the randomized controlled trials of PSA-screening and recommendations from national guidelines groups. The chapter discusses the role of the PSA-test as a tool to discriminate clinically significant from indolent prostate cancer at prostate biopsy as well as the growing evidence regarding its role as a risk-stratification tool and prognostic marker of future lethal prostate cancer.

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Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
biomarkers, monitoring, Prostate cancer, prostate-specific antigen, PSA, screening, treatment
host publication
Cancer Biomarkers : Clinical Aspects and Laboratory Determination - Clinical Aspects and Laboratory Determination
pages
42 pages
publisher
ScienceDirect, Elsevier
external identifiers
  • scopus:85137891053
ISBN
9780128243039
9780128243022
DOI
10.1016/B978-0-12-824302-2.00001-1
language
English
LU publication?
yes
id
48a59705-e379-4985-aceb-5b38d79a6a12
date added to LUP
2022-12-05 12:57:45
date last changed
2024-06-27 22:23:30
@inbook{48a59705-e379-4985-aceb-5b38d79a6a12,
  abstract     = {{<p>The test used for early detection and monitoring of prostate cancer—prostate-specific antigen (PSA)—is one of the most accurate and frequently used tumor markers in medicine today. No tumor marker has had such a critical impact on early detection through stage-migration, and monitoring after treatment for prostate cancer as the blood test PSA. This chapter provides an overview of the PSA test and its distinct molecular forms in blood, in screening, early detection and monitoring of prostate cancer. This chapter gives a summary of the randomized controlled trials of PSA-screening and recommendations from national guidelines groups. The chapter discusses the role of the PSA-test as a tool to discriminate clinically significant from indolent prostate cancer at prostate biopsy as well as the growing evidence regarding its role as a risk-stratification tool and prognostic marker of future lethal prostate cancer.</p>}},
  author       = {{Carlsson, Sigrid V. and Murata, Kazunori and Danila, Daniel C. and Lilja, Hans}},
  booktitle    = {{Cancer Biomarkers : Clinical Aspects and Laboratory Determination}},
  isbn         = {{9780128243039}},
  keywords     = {{biomarkers; monitoring; Prostate cancer; prostate-specific antigen; PSA; screening; treatment}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{131--172}},
  publisher    = {{ScienceDirect, Elsevier}},
  title        = {{PSA : role in screening and monitoring patients with prostate cancer}},
  url          = {{http://dx.doi.org/10.1016/B978-0-12-824302-2.00001-1}},
  doi          = {{10.1016/B978-0-12-824302-2.00001-1}},
  year         = {{2022}},
}