Effect of cobalt and chromium ions on the chlorhexidine digluconate as seen by intermolecular diffusion
Fangaia, Sónia I.G. ; Nicolau, Pedro M.G. ; Guerra, Fernando A.D.R.A. ; Melia Rodrigo, M. ; Utzeri, Gianluca LU
; Cabral, Ana M.T.D.P.V.
; Valente, Artur J.M.
; Esteso, Miguel A.
and Ribeiro, Ana C.F.
(2021)
In International Journal of Molecular Sciences
22(24).
- Abstract
Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of... (More)
Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth.
(Less)
- author
- Fangaia, Sónia I.G.
; Nicolau, Pedro M.G.
; Guerra, Fernando A.D.R.A.
; Melia Rodrigo, M.
; Utzeri, Gianluca
LU
; Cabral, Ana M.T.D.P.V.
; Valente, Artur J.M.
; Esteso, Miguel A.
and Ribeiro, Ana C.F.
- publishing date
- 2021-12-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Artificial saliva, Chlorhexidine digluconate, Chromium chloride, Cobalt chloride, Diffusion coefficients
- in
- International Journal of Molecular Sciences
- volume
- 22
- issue
- 24
- article number
- 13266
- publisher
- MDPI AG
- external identifiers
-
- scopus:85120755403
- pmid:34948060
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms222413266
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- id
- 48b79ff6-37b7-4cc5-84e8-8464647c0e8e
- date added to LUP
- 2024-07-22 10:52:56
- date last changed
- 2024-08-15 10:07:43
@article{48b79ff6-37b7-4cc5-84e8-8464647c0e8e,
abstract = {{<p>Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth.</p>}},
author = {{Fangaia, Sónia I.G. and Nicolau, Pedro M.G. and Guerra, Fernando A.D.R.A. and Melia Rodrigo, M. and Utzeri, Gianluca and Cabral, Ana M.T.D.P.V. and Valente, Artur J.M. and Esteso, Miguel A. and Ribeiro, Ana C.F.}},
issn = {{1661-6596}},
keywords = {{Artificial saliva; Chlorhexidine digluconate; Chromium chloride; Cobalt chloride; Diffusion coefficients}},
language = {{eng}},
month = {{12}},
number = {{24}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{Effect of cobalt and chromium ions on the chlorhexidine digluconate as seen by intermolecular diffusion}},
url = {{http://dx.doi.org/10.3390/ijms222413266}},
doi = {{10.3390/ijms222413266}},
volume = {{22}},
year = {{2021}},
}