Effects of oophorectomy, sympathetic denervation and sex steroids on uterine norepinephrine content and myometrial contractile response to norepinephrine in the guinea pig
(1990) In Neuroendocrinology 52(4). p.332-336- Abstract
- Studies were performed in guinea pigs to elucidate alterations in endogenous uterine norepinephrine (NE) levels and changes in the contractile response to exogenous NE following local sympathetic denervation, oophorectomy, or treatment with sex steroids. Both in intact and oophorectomized animals the myometrial NE concentration was reduced after sex steroid treatment (0.5 microgram 17-beta-estradiol, or 0.1 microgram estradiol plus 2 mg progesterone, during 2 weeks), mainly as a result of increased uterine weight. After surgical removal of the hypogastric nerves and section of the suspensory ligaments, a similar response to sex steroids was seen if the animals had previously been oophorectomized. The myometrial contractile activity induced... (More)
- Studies were performed in guinea pigs to elucidate alterations in endogenous uterine norepinephrine (NE) levels and changes in the contractile response to exogenous NE following local sympathetic denervation, oophorectomy, or treatment with sex steroids. Both in intact and oophorectomized animals the myometrial NE concentration was reduced after sex steroid treatment (0.5 microgram 17-beta-estradiol, or 0.1 microgram estradiol plus 2 mg progesterone, during 2 weeks), mainly as a result of increased uterine weight. After surgical removal of the hypogastric nerves and section of the suspensory ligaments, a similar response to sex steroids was seen if the animals had previously been oophorectomized. The myometrial contractile activity induced by exogenous NE was measured in vitro. The EC50 values (NE concentration giving 50% of the maximal response) showed a similar pattern of variations after hormonal treatment and oophorectomy as did the concentration of endogenous NE. Thus, exposure to the steroids leading to a reduction of neuronal NE also caused an increased sensitivity of the myometrial smooth musculature to exogenous NE, and in the various experimental groups the two parameters showed a close and significant relationship. The underlying mechanism may induce a denervation supersensitivity to NE induced by exposure to estrogen and progesterone. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105320
- author
- Rydhström, Håkan ; Walles, Bengt and Owman, Christer LU
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Norepinephrine, Oophorectomy, Sympathetic denervation, Guinea pig, Myometrial contraction
- in
- Neuroendocrinology
- volume
- 52
- issue
- 4
- pages
- 332 - 336
- publisher
- Karger
- external identifiers
-
- pmid:2124659
- scopus:0025053249
- ISSN
- 0028-3835
- language
- English
- LU publication?
- yes
- id
- 48c21803-94ce-4b66-8db3-505117b54337 (old id 1105320)
- date added to LUP
- 2016-04-01 12:13:57
- date last changed
- 2021-01-03 03:18:00
@article{48c21803-94ce-4b66-8db3-505117b54337,
abstract = {{Studies were performed in guinea pigs to elucidate alterations in endogenous uterine norepinephrine (NE) levels and changes in the contractile response to exogenous NE following local sympathetic denervation, oophorectomy, or treatment with sex steroids. Both in intact and oophorectomized animals the myometrial NE concentration was reduced after sex steroid treatment (0.5 microgram 17-beta-estradiol, or 0.1 microgram estradiol plus 2 mg progesterone, during 2 weeks), mainly as a result of increased uterine weight. After surgical removal of the hypogastric nerves and section of the suspensory ligaments, a similar response to sex steroids was seen if the animals had previously been oophorectomized. The myometrial contractile activity induced by exogenous NE was measured in vitro. The EC50 values (NE concentration giving 50% of the maximal response) showed a similar pattern of variations after hormonal treatment and oophorectomy as did the concentration of endogenous NE. Thus, exposure to the steroids leading to a reduction of neuronal NE also caused an increased sensitivity of the myometrial smooth musculature to exogenous NE, and in the various experimental groups the two parameters showed a close and significant relationship. The underlying mechanism may induce a denervation supersensitivity to NE induced by exposure to estrogen and progesterone.}},
author = {{Rydhström, Håkan and Walles, Bengt and Owman, Christer}},
issn = {{0028-3835}},
keywords = {{Norepinephrine; Oophorectomy; Sympathetic denervation; Guinea pig; Myometrial contraction}},
language = {{eng}},
number = {{4}},
pages = {{332--336}},
publisher = {{Karger}},
series = {{Neuroendocrinology}},
title = {{Effects of oophorectomy, sympathetic denervation and sex steroids on uterine norepinephrine content and myometrial contractile response to norepinephrine in the guinea pig}},
volume = {{52}},
year = {{1990}},
}