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The complex relationship between liver cancer and the cell cycle : A story of multiple regulations

Bisteau, Xavier ; Caldez, Matias J. and Kaldis, Philipp LU (2014) In Cancers 6(1). p.79-111
Abstract

The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Cancer, Cell cycle, CKI, Cyclin-dependent kinases, Cyclins, Hepatocellular carcinoma, Liver
in
Cancers
volume
6
issue
1
pages
33 pages
publisher
Multidisciplinary Digital Publishing Institute (MDPI)
external identifiers
  • scopus:84893366848
ISSN
2072-6694
DOI
10.3390/cancers6010079
language
English
LU publication?
no
id
48e8ba96-211b-467d-b0cb-15df7911f093
date added to LUP
2019-09-18 13:55:45
date last changed
2020-01-13 02:23:48
@article{48e8ba96-211b-467d-b0cb-15df7911f093,
  abstract     = {<p>The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.</p>},
  author       = {Bisteau, Xavier and Caldez, Matias J. and Kaldis, Philipp},
  issn         = {2072-6694},
  language     = {eng},
  month        = {03},
  number       = {1},
  pages        = {79--111},
  publisher    = {Multidisciplinary Digital Publishing Institute (MDPI)},
  series       = {Cancers},
  title        = {The complex relationship between liver cancer and the cell cycle : A story of multiple regulations},
  url          = {http://dx.doi.org/10.3390/cancers6010079},
  doi          = {10.3390/cancers6010079},
  volume       = {6},
  year         = {2014},
}