Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis : Results From the Population-Based SCAPIS Project
(2023) In Mayo Clinic Proceedings- Abstract
Objective: To examine the associations between the American Heart Association scores (“Life's Essential 8” [LE8] and “Life's Simple 7” [LS7]) and 2 subclinical coronary atherosclerosis indicators: coronary computed tomographic angiography (CCTA)-stenosis and coronary artery calcium (CAC). Patients and Methods: We included a population-based sample, aged 50 to 64 years, recruited between 2013 and 2018 from the Swedish Cardiopulmonary Bioimage Study (n=24,819, 50.3% women). CCTA-stenosis was graded as no stenosis, stenosis (1%-49%) or severe stenosis (≥50%), whereas CAC was graded as 0, 1 to 99, 100 to 399, or ≥400 Agatston units. Multinomial logistic regression and receiver operating characteristic (ROC) curves were used to study the... (More)
Objective: To examine the associations between the American Heart Association scores (“Life's Essential 8” [LE8] and “Life's Simple 7” [LS7]) and 2 subclinical coronary atherosclerosis indicators: coronary computed tomographic angiography (CCTA)-stenosis and coronary artery calcium (CAC). Patients and Methods: We included a population-based sample, aged 50 to 64 years, recruited between 2013 and 2018 from the Swedish Cardiopulmonary Bioimage Study (n=24,819, 50.3% women). CCTA-stenosis was graded as no stenosis, stenosis (1%-49%) or severe stenosis (≥50%), whereas CAC was graded as 0, 1 to 99, 100 to 399, or ≥400 Agatston units. Multinomial logistic regression and receiver operating characteristic (ROC) curves were used to study the associations between cardiovascular health scores and subclinical coronary atherosclerosis. Results: Odds ratios (ORs) for CCTA-stenosis and severe CCTA-stenosis between the lowest (<50 points) vs the highest (≥80 points) LE8 group were 4.18 (95% CI, 3.56 to 4.91) and 11.17 (95% CI, 8.36 to 14.93), respectively. For corresponding CAC results, ORs were 3.36 (95% CI, 2.84 to 3.98), 7.72 (95% CI, 6.03 to 9.89), and 14.94 (95% CI, 10.47 to 21.31) for CAC scores of 1 to 99, 100 to 399, and ≥400, respectively. Area under ROC curves for predicting any stenosis were 0.642 (95% CI, 0.635 to 0.649) and 0.631 (95% CI, 0.624 to 0.638, P<.001) for LE8 and LS7, respectively. Conclusion: Our data indicate that LE8 showed a strong, graded, and inverse association with CCTA-stenosis and CAC score. The capacity to predict CCTA-stenosis was comparable between LE8 and LS7, although LE8 had slightly higher prediction capacity of any stenosis. This study provides novel evidence that the LE8 score may be a useful tool for monitoring cardiovascular health.
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- organization
- publishing date
- 2023
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- publication status
- epub
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- in
- Mayo Clinic Proceedings
- publisher
- Mayo Clinic Proceedings
- external identifiers
-
- pmid:37843486
- scopus:85173854770
- ISSN
- 0025-6196
- DOI
- 10.1016/j.mayocp.2023.03.023
- language
- English
- LU publication?
- yes
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- 48efea77-f8b8-461b-9bff-a1145839e770
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@article{48efea77-f8b8-461b-9bff-a1145839e770,
abstract = {{<p>Objective: To examine the associations between the American Heart Association scores (“Life's Essential 8” [LE8] and “Life's Simple 7” [LS7]) and 2 subclinical coronary atherosclerosis indicators: coronary computed tomographic angiography (CCTA)-stenosis and coronary artery calcium (CAC). Patients and Methods: We included a population-based sample, aged 50 to 64 years, recruited between 2013 and 2018 from the Swedish Cardiopulmonary Bioimage Study (n=24,819, 50.3% women). CCTA-stenosis was graded as no stenosis, stenosis (1%-49%) or severe stenosis (≥50%), whereas CAC was graded as 0, 1 to 99, 100 to 399, or ≥400 Agatston units. Multinomial logistic regression and receiver operating characteristic (ROC) curves were used to study the associations between cardiovascular health scores and subclinical coronary atherosclerosis. Results: Odds ratios (ORs) for CCTA-stenosis and severe CCTA-stenosis between the lowest (<50 points) vs the highest (≥80 points) LE8 group were 4.18 (95% CI, 3.56 to 4.91) and 11.17 (95% CI, 8.36 to 14.93), respectively. For corresponding CAC results, ORs were 3.36 (95% CI, 2.84 to 3.98), 7.72 (95% CI, 6.03 to 9.89), and 14.94 (95% CI, 10.47 to 21.31) for CAC scores of 1 to 99, 100 to 399, and ≥400, respectively. Area under ROC curves for predicting any stenosis were 0.642 (95% CI, 0.635 to 0.649) and 0.631 (95% CI, 0.624 to 0.638, P<.001) for LE8 and LS7, respectively. Conclusion: Our data indicate that LE8 showed a strong, graded, and inverse association with CCTA-stenosis and CAC score. The capacity to predict CCTA-stenosis was comparable between LE8 and LS7, although LE8 had slightly higher prediction capacity of any stenosis. This study provides novel evidence that the LE8 score may be a useful tool for monitoring cardiovascular health.</p>}},
author = {{Herraiz-Adillo, Ángel and Higueras-Fresnillo, Sara and Ahlqvist, Viktor H. and Berglind, Daniel and Syrjälä, Maria B. and Daka, Bledar and Lenander, Cecilia and Sundström, Johan and Ortega, Francisco B. and Östgren, Carl Johan and Rådholm, Karin and Henriksson, Pontus}},
issn = {{0025-6196}},
language = {{eng}},
publisher = {{Mayo Clinic Proceedings}},
series = {{Mayo Clinic Proceedings}},
title = {{Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis : Results From the Population-Based SCAPIS Project}},
url = {{http://dx.doi.org/10.1016/j.mayocp.2023.03.023}},
doi = {{10.1016/j.mayocp.2023.03.023}},
year = {{2023}},
}