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TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells.

Fasching, Liana LU ; Kapopoulou, Adamandia; Sachdeva, Rohit LU ; Petri, Rebecca LU ; Jönsson, Marie LU ; Männe, Christian LU ; Turelli, Priscilla; Jern, Patric; Cammas, Florence and Trono, Didier, et al. (2015) In Cell Reports 10(1). p.20-28
Abstract
TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future... (More)
TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future studies on the role of ERVs in the healthy and diseased brain. (Less)
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published
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Cell Reports
volume
10
issue
1
pages
20 - 28
publisher
Cell Press
external identifiers
  • pmid:25543143
  • wos:000347465600003
  • scopus:84920923006
ISSN
2211-1247
DOI
10.1016/j.celrep.2014.12.004
language
English
LU publication?
yes
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01c7791a-bc91-4563-88cf-7afb26bc1059 (old id 4905534)
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http://www.ncbi.nlm.nih.gov/pubmed/25543143?dopt=Abstract
date added to LUP
2015-01-06 11:46:19
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2017-11-05 03:50:46
@article{01c7791a-bc91-4563-88cf-7afb26bc1059,
  abstract     = {TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future studies on the role of ERVs in the healthy and diseased brain.},
  author       = {Fasching, Liana and Kapopoulou, Adamandia and Sachdeva, Rohit and Petri, Rebecca and Jönsson, Marie and Männe, Christian and Turelli, Priscilla and Jern, Patric and Cammas, Florence and Trono, Didier and Jakobsson, Johan},
  issn         = {2211-1247},
  language     = {eng},
  number       = {1},
  pages        = {20--28},
  publisher    = {Cell Press},
  series       = {Cell Reports},
  title        = {TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells.},
  url          = {http://dx.doi.org/10.1016/j.celrep.2014.12.004},
  volume       = {10},
  year         = {2015},
}