Vaccine for Atherosclerosis.
(2014) In Journal of the American College of Cardiology 64(25). p.2779-2791- Abstract
- Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. This review discusses: 1) the complex role of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature of many antigens that have been tested successfully in vaccine formulations to reduce atherosclerosis in pre-clinical... (More)
- Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. This review discusses: 1) the complex role of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature of many antigens that have been tested successfully in vaccine formulations to reduce atherosclerosis in pre-clinical experimental models; and 3) the potential opportunities and challenges for clinical application of vaccination for atherosclerosis in the future. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4905622
- author
- Shah, Prediman K ; Chyu, Kuang-Yuh ; Dimayuga, Paul C and Nilsson, Jan LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the American College of Cardiology
- volume
- 64
- issue
- 25
- pages
- 2779 - 2791
- publisher
- Elsevier
- external identifiers
-
- pmid:25541132
- wos:000346734900011
- scopus:84919625904
- pmid:25541132
- ISSN
- 0735-1097
- DOI
- 10.1016/j.jacc.2014.10.018
- language
- English
- LU publication?
- yes
- id
- d021a3e2-304e-44ad-9009-6f541fb35efe (old id 4905622)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25541132?dopt=Abstract
- date added to LUP
- 2016-04-01 10:51:34
- date last changed
- 2022-02-10 06:39:14
@article{d021a3e2-304e-44ad-9009-6f541fb35efe,
abstract = {{Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. This review discusses: 1) the complex role of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature of many antigens that have been tested successfully in vaccine formulations to reduce atherosclerosis in pre-clinical experimental models; and 3) the potential opportunities and challenges for clinical application of vaccination for atherosclerosis in the future.}},
author = {{Shah, Prediman K and Chyu, Kuang-Yuh and Dimayuga, Paul C and Nilsson, Jan}},
issn = {{0735-1097}},
language = {{eng}},
number = {{25}},
pages = {{2779--2791}},
publisher = {{Elsevier}},
series = {{Journal of the American College of Cardiology}},
title = {{Vaccine for Atherosclerosis.}},
url = {{http://dx.doi.org/10.1016/j.jacc.2014.10.018}},
doi = {{10.1016/j.jacc.2014.10.018}},
volume = {{64}},
year = {{2014}},
}