Advanced

Vaccine for Atherosclerosis.

Shah, Prediman K; Chyu, Kuang-Yuh; Dimayuga, Paul C and Nilsson, Jan LU (2014) In Journal of the American College of Cardiology 64(25). p.2779-2791
Abstract
Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. This review discusses: 1) the complex role of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature of many antigens that have been tested successfully in vaccine formulations to reduce atherosclerosis in pre-clinical... (More)
Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. This review discusses: 1) the complex role of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature of many antigens that have been tested successfully in vaccine formulations to reduce atherosclerosis in pre-clinical experimental models; and 3) the potential opportunities and challenges for clinical application of vaccination for atherosclerosis in the future. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the American College of Cardiology
volume
64
issue
25
pages
2779 - 2791
publisher
Elsevier USA
external identifiers
  • pmid:25541132
  • wos:000346734900011
  • scopus:84919625904
ISSN
0735-1097
DOI
10.1016/j.jacc.2014.10.018
language
English
LU publication?
yes
id
d021a3e2-304e-44ad-9009-6f541fb35efe (old id 4905622)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25541132?dopt=Abstract
date added to LUP
2015-01-06 11:52:12
date last changed
2017-11-12 03:13:02
@article{d021a3e2-304e-44ad-9009-6f541fb35efe,
  abstract     = {Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. This review discusses: 1) the complex role of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature of many antigens that have been tested successfully in vaccine formulations to reduce atherosclerosis in pre-clinical experimental models; and 3) the potential opportunities and challenges for clinical application of vaccination for atherosclerosis in the future.},
  author       = {Shah, Prediman K and Chyu, Kuang-Yuh and Dimayuga, Paul C and Nilsson, Jan},
  issn         = {0735-1097},
  language     = {eng},
  number       = {25},
  pages        = {2779--2791},
  publisher    = {Elsevier USA},
  series       = {Journal of the American College of Cardiology},
  title        = {Vaccine for Atherosclerosis.},
  url          = {http://dx.doi.org/10.1016/j.jacc.2014.10.018},
  volume       = {64},
  year         = {2014},
}