Innate immunity and genetic determinants of urinary tract infection susceptibility.
Godaly, Gabriela LU
; Ambite, Ines
LU
and Svanborg, Catharina
LU
(2015)
In Current Opinion in Infectious Diseases
28(1).
p.88-96
- Abstract
- Urinary tract infections (UTIs) are common, dangerous and interesting. Susceptible individuals experience multiple, often clustered episodes, and in a subset of patients, infections progress to acute pyelonephritis (APN), sometimes accompanied by uro-sepsis. Others develop asymptomatic bacteriuria (ABU). Here, we review the molecular basis for these differences, with the intention to distinguish exaggerated host responses that drive disease from attenuated responses that favour protection and to highlight the genetic basis for these extremes, based on knock-out mice and clinical studies.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4905659
- author
- Godaly, Gabriela
LU
; Ambite, Ines
LU
and Svanborg, Catharina
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Infectious Diseases
- volume
- 28
- issue
- 1
- pages
- 88 - 96
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:25539411
- wos:000351434900014
- scopus:84920829514
- pmid:25539411
- ISSN
- 1473-6527
- DOI
- 10.1097/QCO.0000000000000127
- language
- English
- LU publication?
- yes
- id
- 4182da4d-44f1-4779-bf9c-09ff0fb059d3 (old id 4905659)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25539411?dopt=Abstract
- date added to LUP
- 2016-04-01 10:05:07
- date last changed
- 2023-08-30 16:43:10
@article{4182da4d-44f1-4779-bf9c-09ff0fb059d3,
abstract = {{Urinary tract infections (UTIs) are common, dangerous and interesting. Susceptible individuals experience multiple, often clustered episodes, and in a subset of patients, infections progress to acute pyelonephritis (APN), sometimes accompanied by uro-sepsis. Others develop asymptomatic bacteriuria (ABU). Here, we review the molecular basis for these differences, with the intention to distinguish exaggerated host responses that drive disease from attenuated responses that favour protection and to highlight the genetic basis for these extremes, based on knock-out mice and clinical studies.}},
author = {{Godaly, Gabriela and Ambite, Ines and Svanborg, Catharina}},
issn = {{1473-6527}},
language = {{eng}},
number = {{1}},
pages = {{88--96}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Current Opinion in Infectious Diseases}},
title = {{Innate immunity and genetic determinants of urinary tract infection susceptibility.}},
url = {{http://dx.doi.org/10.1097/QCO.0000000000000127}},
doi = {{10.1097/QCO.0000000000000127}},
volume = {{28}},
year = {{2015}},
}