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Innate immunity and genetic determinants of urinary tract infection susceptibility.

Godaly, Gabriela LU ; Ambite, Ines LU and Svanborg, Catharina LU (2015) In Current Opinion in Infectious Diseases 28(1). p.88-96
Abstract
Urinary tract infections (UTIs) are common, dangerous and interesting. Susceptible individuals experience multiple, often clustered episodes, and in a subset of patients, infections progress to acute pyelonephritis (APN), sometimes accompanied by uro-sepsis. Others develop asymptomatic bacteriuria (ABU). Here, we review the molecular basis for these differences, with the intention to distinguish exaggerated host responses that drive disease from attenuated responses that favour protection and to highlight the genetic basis for these extremes, based on knock-out mice and clinical studies.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Infectious Diseases
volume
28
issue
1
pages
88 - 96
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:25539411
  • wos:000351434900014
  • scopus:84920829514
ISSN
1473-6527
DOI
10.1097/QCO.0000000000000127
language
English
LU publication?
yes
id
4182da4d-44f1-4779-bf9c-09ff0fb059d3 (old id 4905659)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25539411?dopt=Abstract
date added to LUP
2015-01-06 12:03:05
date last changed
2017-10-01 03:06:50
@article{4182da4d-44f1-4779-bf9c-09ff0fb059d3,
  abstract     = {Urinary tract infections (UTIs) are common, dangerous and interesting. Susceptible individuals experience multiple, often clustered episodes, and in a subset of patients, infections progress to acute pyelonephritis (APN), sometimes accompanied by uro-sepsis. Others develop asymptomatic bacteriuria (ABU). Here, we review the molecular basis for these differences, with the intention to distinguish exaggerated host responses that drive disease from attenuated responses that favour protection and to highlight the genetic basis for these extremes, based on knock-out mice and clinical studies.},
  author       = {Godaly, Gabriela and Ambite, Ines and Svanborg, Catharina},
  issn         = {1473-6527},
  language     = {eng},
  number       = {1},
  pages        = {88--96},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Infectious Diseases},
  title        = {Innate immunity and genetic determinants of urinary tract infection susceptibility.},
  url          = {http://dx.doi.org/10.1097/QCO.0000000000000127},
  volume       = {28},
  year         = {2015},
}