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Disturbance of posture in children with very low lead exposure, and modification by VDR FokI genotype.

Pawlas, Natalia; Broberg Palmgren, Karin LU ; Skerfving, Staffan LU and Pawlas, Krystyna (2014) In Annals of Agricultural and Environmental Medicine 21(4). p.739-744
Abstract
Introduction and objective. Lead has a negative effect on the central nervous system (CNS), inter alia indicated by disturbance of posture. However, knowledge of the CNS effects at low exposure is insufficient. Individuals differ in vulnerability, possibly because of genetic predisposition. Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity. The objective of the study was to determine whether very low lead exposure affects posture in children, and whether ALAD and VDR genotypes modify the effect. Materials and methods. In 1996-2001, 108 (age 5-13, mean 6.9), and in 2008-2010 231 (age 5-11, mean 7.9) children from Poland were tested by posturography... (More)
Introduction and objective. Lead has a negative effect on the central nervous system (CNS), inter alia indicated by disturbance of posture. However, knowledge of the CNS effects at low exposure is insufficient. Individuals differ in vulnerability, possibly because of genetic predisposition. Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity. The objective of the study was to determine whether very low lead exposure affects posture in children, and whether ALAD and VDR genotypes modify the effect. Materials and methods. In 1996-2001, 108 (age 5-13, mean 6.9), and in 2008-2010 231 (age 5-11, mean 7.9) children from Poland were tested by posturography and blood-lead concentration (B-Pb; medians 50 and 36 µg/L, respectively). The children were genotyped for ALAD (RsaI, MspI) and VDR (FokI, BsmI, TaqI). Results. There were correlations between posture and B-Pb (sway area with closed eyes: rS=0.24, P<0.001; velocity: rS=0.21, P<0.001). Significant effects (adjusted for the potential confounders height and mother´s education) were present already at (ln-transformed) B-Pb <50 µg/L [β (regression coefficient) for sway area 0.025, p=0.001), and even stronger than at higher levels (β=0.006, p=0.06, respectively)]. The ff carriers in VDR FokI polymorphism were more susceptible to the effect of lead on the balance system, while other VDR or ALAD genotypes did not significantly modify the effect. Conclusions. Effects on CNS, as reflected by disturbances of posture, were present at very low lead exposure (B-Pb <50 µg/L), and the effect was significantly greater at such low B-Pbs than at higher. VDR FokI significantly modified the effect. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Annals of Agricultural and Environmental Medicine
volume
21
issue
4
pages
739 - 744
publisher
Institute of Agricultural Medicine in Lublin, Poland
external identifiers
  • pmid:25528913
  • wos:000346625800015
  • scopus:84915756535
ISSN
1898-2263
DOI
10.5604/12321966.1129926
language
English
LU publication?
yes
id
5a94ac04-201c-4b11-9360-88838ba3579f (old id 4905840)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25528913?dopt=Abstract
date added to LUP
2015-01-07 14:33:34
date last changed
2017-01-01 04:16:26
@article{5a94ac04-201c-4b11-9360-88838ba3579f,
  abstract     = {Introduction and objective. Lead has a negative effect on the central nervous system (CNS), inter alia indicated by disturbance of posture. However, knowledge of the CNS effects at low exposure is insufficient. Individuals differ in vulnerability, possibly because of genetic predisposition. Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity. The objective of the study was to determine whether very low lead exposure affects posture in children, and whether ALAD and VDR genotypes modify the effect. Materials and methods. In 1996-2001, 108 (age 5-13, mean 6.9), and in 2008-2010 231 (age 5-11, mean 7.9) children from Poland were tested by posturography and blood-lead concentration (B-Pb; medians 50 and 36 µg/L, respectively). The children were genotyped for ALAD (RsaI, MspI) and VDR (FokI, BsmI, TaqI). Results. There were correlations between posture and B-Pb (sway area with closed eyes: rS=0.24, P&lt;0.001; velocity: rS=0.21, P&lt;0.001). Significant effects (adjusted for the potential confounders height and mother´s education) were present already at (ln-transformed) B-Pb &lt;50 µg/L [β (regression coefficient) for sway area 0.025, p=0.001), and even stronger than at higher levels (β=0.006, p=0.06, respectively)]. The ff carriers in VDR FokI polymorphism were more susceptible to the effect of lead on the balance system, while other VDR or ALAD genotypes did not significantly modify the effect. Conclusions. Effects on CNS, as reflected by disturbances of posture, were present at very low lead exposure (B-Pb &lt;50 µg/L), and the effect was significantly greater at such low B-Pbs than at higher. VDR FokI significantly modified the effect.},
  author       = {Pawlas, Natalia and Broberg Palmgren, Karin and Skerfving, Staffan and Pawlas, Krystyna},
  issn         = {1898-2263},
  language     = {eng},
  number       = {4},
  pages        = {739--744},
  publisher    = {Institute of Agricultural Medicine in Lublin, Poland},
  series       = {Annals of Agricultural and Environmental Medicine},
  title        = {Disturbance of posture in children with very low lead exposure, and modification by VDR FokI genotype.},
  url          = {http://dx.doi.org/10.5604/12321966.1129926},
  volume       = {21},
  year         = {2014},
}