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Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2: FiO2-Ratio Early After Major Burns.

Johansson, Joakim ; Steinvall, Ingrid ; Herwald, Heiko LU orcid ; Lindbom, Lennart and Sjöberg, Folke (2015) In Journal of Burn Care & Research 36(4). p.484-492
Abstract
Leukocytes are activated systemically and their numbers increase soon after a burn followed by a rapid decline to low normal or subnormal levels, possibly by increased extravasation. Experimental data support that an important target for such extravasation is the lungs and that leukocytes when they adhere to endothelial cells cause an increase in vascular permeability. The authors investigated a possible relation between early increased pulmonary vascular permeability or a decreased PaO2:FiO2-ratio and the dynamic change in concentration of blood leukocytes after a burn. This is a prospective, exploratory, single-center study. The authors measured the dynamic changes of leukocytes in blood starting early after the burn, pulmonary vascular... (More)
Leukocytes are activated systemically and their numbers increase soon after a burn followed by a rapid decline to low normal or subnormal levels, possibly by increased extravasation. Experimental data support that an important target for such extravasation is the lungs and that leukocytes when they adhere to endothelial cells cause an increase in vascular permeability. The authors investigated a possible relation between early increased pulmonary vascular permeability or a decreased PaO2:FiO2-ratio and the dynamic change in concentration of blood leukocytes after a burn. This is a prospective, exploratory, single-center study. The authors measured the dynamic changes of leukocytes in blood starting early after the burn, pulmonary vascular permeability index by thermodilution, and PaO2:FiO2-ratios in 20 patients during the first 21 days after a major burn (>20% TBSA%). Median TBSA was 40% interquartile range (IQR, 25-52) and full thickness burn 28% (IQR, 2-39). There was a correlation between the early (<24 hours) alteration in white blood cell count and both early increased pulmonary vascular permeability (r = .63, P = .004) and the decreased oxygenation index defined as PaO2:FiO2 < 27 kPa (P = .004). The authors have documented a correlation between dynamic change of blood leukocytes and pulmonary failure early after burns. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Burn Care & Research
volume
36
issue
4
pages
484 - 492
publisher
Oxford University Press
external identifiers
  • pmid:25501784
  • wos:000358288900005
  • scopus:84937642484
  • pmid:25501784
ISSN
1559-0488
DOI
10.1097/BCR.0000000000000211
language
English
LU publication?
yes
id
70b1858c-3047-433c-aa66-1924119b6ad9 (old id 4908405)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25501784?dopt=Abstract
date added to LUP
2016-04-01 10:15:20
date last changed
2025-04-04 14:02:17
@article{70b1858c-3047-433c-aa66-1924119b6ad9,
  abstract     = {{Leukocytes are activated systemically and their numbers increase soon after a burn followed by a rapid decline to low normal or subnormal levels, possibly by increased extravasation. Experimental data support that an important target for such extravasation is the lungs and that leukocytes when they adhere to endothelial cells cause an increase in vascular permeability. The authors investigated a possible relation between early increased pulmonary vascular permeability or a decreased PaO2:FiO2-ratio and the dynamic change in concentration of blood leukocytes after a burn. This is a prospective, exploratory, single-center study. The authors measured the dynamic changes of leukocytes in blood starting early after the burn, pulmonary vascular permeability index by thermodilution, and PaO2:FiO2-ratios in 20 patients during the first 21 days after a major burn (&gt;20% TBSA%). Median TBSA was 40% interquartile range (IQR, 25-52) and full thickness burn 28% (IQR, 2-39). There was a correlation between the early (&lt;24 hours) alteration in white blood cell count and both early increased pulmonary vascular permeability (r = .63, P = .004) and the decreased oxygenation index defined as PaO2:FiO2 &lt; 27 kPa (P = .004). The authors have documented a correlation between dynamic change of blood leukocytes and pulmonary failure early after burns.}},
  author       = {{Johansson, Joakim and Steinvall, Ingrid and Herwald, Heiko and Lindbom, Lennart and Sjöberg, Folke}},
  issn         = {{1559-0488}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{484--492}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Burn Care & Research}},
  title        = {{Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2: FiO2-Ratio Early After Major Burns.}},
  url          = {{http://dx.doi.org/10.1097/BCR.0000000000000211}},
  doi          = {{10.1097/BCR.0000000000000211}},
  volume       = {{36}},
  year         = {{2015}},
}