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Relationships between tissue composition and viscoelastic properties in human trabecular bone.

Ojanen, X; Isaksson, Hanna LU ; Töyräs, J; Turunen, M J; Malo, M K H; Halvari, A and Jurvelin, J S (2015) In Journal of Biomechanics 48(2). p.269-275
Abstract
Trabecular bone is a metabolically active tissue with a high surface to volume ratio. It exhibits viscoelastic properties that may change during aging. Changes in bone properties due to altered metabolism are sensitively revealed in trabecular bone. However, the relationships between material composition and viscoelastic properties of bone, and their changes during aging have not yet been elucidated. In this study, trabecular bone samples from the femoral neck of male cadavers (n=21) aged 17-82 years were collected and the tissue level composition and its associations with the tissue viscoelastic properties were evaluated by using Raman microspectroscopy and nanoindentation, respectively. For composition, collagen content, mineralization,... (More)
Trabecular bone is a metabolically active tissue with a high surface to volume ratio. It exhibits viscoelastic properties that may change during aging. Changes in bone properties due to altered metabolism are sensitively revealed in trabecular bone. However, the relationships between material composition and viscoelastic properties of bone, and their changes during aging have not yet been elucidated. In this study, trabecular bone samples from the femoral neck of male cadavers (n=21) aged 17-82 years were collected and the tissue level composition and its associations with the tissue viscoelastic properties were evaluated by using Raman microspectroscopy and nanoindentation, respectively. For composition, collagen content, mineralization, carbonate substitution and mineral crystallinity were evaluated. The calculated mechanical properties included reduced modulus (Er), hardness (H) and the creep parameters (E1, E2, η1and η2), as obtained by fitting the experimental data to the Burgers model. The results indicated that the creep parameters, E1, E2, η1and η2, were linearly correlated with mineral crystallinity (r=0.769-0.924, p<0.001). Creep time constant (η2/E2) tended to increase with crystallinity (r=0.422, p=0.057). With age, the mineralization decreased (r=-0.587, p=0.005) while the carbonate substitution increased (r=0.728, p<0.001). Age showed no significant associations with nanoindentation parameters. The present findings suggest that, at the tissue-level, the viscoelastic properties of trabecular bone are related to the changes in characteristics of bone mineral. This association may be independent of human age. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biomechanics
volume
48
issue
2
pages
269 - 275
publisher
Elsevier
external identifiers
  • pmid:25498367
  • wos:000349194800012
  • scopus:84920131366
ISSN
1873-2380
DOI
10.1016/j.jbiomech.2014.11.034
language
English
LU publication?
yes
id
5091bdd9-cb8a-499a-8e38-e8d0dd0d1005 (old id 4908523)
date added to LUP
2015-01-12 12:37:15
date last changed
2017-08-06 03:00:35
@article{5091bdd9-cb8a-499a-8e38-e8d0dd0d1005,
  abstract     = {Trabecular bone is a metabolically active tissue with a high surface to volume ratio. It exhibits viscoelastic properties that may change during aging. Changes in bone properties due to altered metabolism are sensitively revealed in trabecular bone. However, the relationships between material composition and viscoelastic properties of bone, and their changes during aging have not yet been elucidated. In this study, trabecular bone samples from the femoral neck of male cadavers (n=21) aged 17-82 years were collected and the tissue level composition and its associations with the tissue viscoelastic properties were evaluated by using Raman microspectroscopy and nanoindentation, respectively. For composition, collagen content, mineralization, carbonate substitution and mineral crystallinity were evaluated. The calculated mechanical properties included reduced modulus (Er), hardness (H) and the creep parameters (E1, E2, η1and η2), as obtained by fitting the experimental data to the Burgers model. The results indicated that the creep parameters, E1, E2, η1and η2, were linearly correlated with mineral crystallinity (r=0.769-0.924, p&lt;0.001). Creep time constant (η2/E2) tended to increase with crystallinity (r=0.422, p=0.057). With age, the mineralization decreased (r=-0.587, p=0.005) while the carbonate substitution increased (r=0.728, p&lt;0.001). Age showed no significant associations with nanoindentation parameters. The present findings suggest that, at the tissue-level, the viscoelastic properties of trabecular bone are related to the changes in characteristics of bone mineral. This association may be independent of human age.},
  author       = {Ojanen, X and Isaksson, Hanna and Töyräs, J and Turunen, M J and Malo, M K H and Halvari, A and Jurvelin, J S},
  issn         = {1873-2380},
  language     = {eng},
  number       = {2},
  pages        = {269--275},
  publisher    = {Elsevier},
  series       = {Journal of Biomechanics},
  title        = {Relationships between tissue composition and viscoelastic properties in human trabecular bone.},
  url          = {http://dx.doi.org/10.1016/j.jbiomech.2014.11.034},
  volume       = {48},
  year         = {2015},
}