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Release of small hydrophilic molecules from polyelectrolyte capsules: Effect of the wall thickness.

Cuomo, Francesca; Lopez, Francesco; Piludu, Marco; Miguel, Maria G; Lindman, Björn LU and Ceglie, Andrea (2015) In Journal of Colloid and Interface Science 447(Online 4 November, 2014). p.211-216
Abstract
Polymer nanocapsules assembled on cationic liposomes have been built through the layer-by-layer (LbL) technique. Chitosan and alginate, two biocompatible polyelectrolytes, were used to cover the template, where the Rhodamine B was previously loaded. The multishell formed with the alternate deposition of the polyelectrolytes, according to the principles of the LbL assembly, was supposed to change the permeability of the capsule wall. The thickness of the multishell was seen increasing with the number of layers deposited through the observations with the Transmission Electron Microscope. The permeability of the capsules was studied through Rhodamine B release assays. Nanocapsules with seven layers of polyelectrolytes released the dye slowly... (More)
Polymer nanocapsules assembled on cationic liposomes have been built through the layer-by-layer (LbL) technique. Chitosan and alginate, two biocompatible polyelectrolytes, were used to cover the template, where the Rhodamine B was previously loaded. The multishell formed with the alternate deposition of the polyelectrolytes, according to the principles of the LbL assembly, was supposed to change the permeability of the capsule wall. The thickness of the multishell was seen increasing with the number of layers deposited through the observations with the Transmission Electron Microscope. The permeability of the capsules was studied through Rhodamine B release assays. Nanocapsules with seven layers of polyelectrolytes released the dye slowly compared to the capsules with three or five layers. The Ritger-Peppas model was applied to investigate the release mechanisms and a non-Fickian transport behavior was detected regardless of the number of layers. Values of diffusion coefficients of Rhodamine B through the capsule wall were also calculated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Colloid and Interface Science
volume
447
issue
Online 4 November, 2014
pages
211 - 216
publisher
Elsevier
external identifiers
  • pmid:25465199
  • wos:000352660600027
  • scopus:84926186935
ISSN
1095-7103
DOI
10.1016/j.jcis.2014.10.060
language
English
LU publication?
yes
id
d24cc9c8-1c7b-4fd0-a6db-580e369366f1 (old id 4912864)
date added to LUP
2015-01-12 17:21:30
date last changed
2017-10-08 03:03:48
@article{d24cc9c8-1c7b-4fd0-a6db-580e369366f1,
  abstract     = {Polymer nanocapsules assembled on cationic liposomes have been built through the layer-by-layer (LbL) technique. Chitosan and alginate, two biocompatible polyelectrolytes, were used to cover the template, where the Rhodamine B was previously loaded. The multishell formed with the alternate deposition of the polyelectrolytes, according to the principles of the LbL assembly, was supposed to change the permeability of the capsule wall. The thickness of the multishell was seen increasing with the number of layers deposited through the observations with the Transmission Electron Microscope. The permeability of the capsules was studied through Rhodamine B release assays. Nanocapsules with seven layers of polyelectrolytes released the dye slowly compared to the capsules with three or five layers. The Ritger-Peppas model was applied to investigate the release mechanisms and a non-Fickian transport behavior was detected regardless of the number of layers. Values of diffusion coefficients of Rhodamine B through the capsule wall were also calculated.},
  author       = {Cuomo, Francesca and Lopez, Francesco and Piludu, Marco and Miguel, Maria G and Lindman, Björn and Ceglie, Andrea},
  issn         = {1095-7103},
  language     = {eng},
  number       = {Online 4 November, 2014},
  pages        = {211--216},
  publisher    = {Elsevier},
  series       = {Journal of Colloid and Interface Science},
  title        = {Release of small hydrophilic molecules from polyelectrolyte capsules: Effect of the wall thickness.},
  url          = {http://dx.doi.org/10.1016/j.jcis.2014.10.060},
  volume       = {447},
  year         = {2015},
}