Advanced

Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.

Brandelius, Angelica LU ; Andersson, Morgan LU and Uller, Lena LU (2014) In Respiratory Medicine 108(12). p.1816-1819
Abstract
Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Medicine
volume
108
issue
12
pages
1816 - 1819
publisher
Elsevier
external identifiers
  • pmid:25456711
  • wos:000347095900012
  • scopus:84927598667
ISSN
1532-3064
DOI
10.1016/j.rmed.2014.10.010
language
English
LU publication?
yes
id
df11e435-2af8-4f21-99fa-b6bb8b66f46e (old id 4913105)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25456711?dopt=Abstract
date added to LUP
2015-01-08 16:57:21
date last changed
2017-11-05 03:14:12
@article{df11e435-2af8-4f21-99fa-b6bb8b66f46e,
  abstract     = {Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.},
  author       = {Brandelius, Angelica and Andersson, Morgan and Uller, Lena},
  issn         = {1532-3064},
  language     = {eng},
  number       = {12},
  pages        = {1816--1819},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.},
  url          = {http://dx.doi.org/10.1016/j.rmed.2014.10.010},
  volume       = {108},
  year         = {2014},
}