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Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.

Reisinger, Kerstin; Hoffmann, Sebastian; Alépée, Nathalie; Ashikaga, Takao; Barroso, Joao; Elcombe, Cliff; Gellatly, Nicola; Galbiati, Valentina; Gibbs, Susan and Groux, Hervé, et al. (2015) In Toxicology in Vitro 29(1). p.259-270
Abstract
The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisation potency prediction. The results of the first phase - systematic evaluation of 16 test methods - are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data, potential for throughput,... (More)
The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisation potency prediction. The results of the first phase - systematic evaluation of 16 test methods - are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data, potential for throughput, transferability and accessibility in cooperation with the test method developers. A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy - combined with bioavailability and skin metabolism data and exposure consideration - is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients. (Less)
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Toxicology in Vitro
volume
29
issue
1
pages
259 - 270
publisher
Elsevier
external identifiers
  • pmid:25448812
  • wos:000347746600034
  • scopus:84912006576
ISSN
1879-3177
DOI
10.1016/j.tiv.2014.10.018
language
English
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yes
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d2201d55-53ae-4778-b1af-a57a807454a4 (old id 4913316)
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2015-01-12 14:18:56
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2017-10-29 03:14:27
@article{d2201d55-53ae-4778-b1af-a57a807454a4,
  abstract     = {The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisation potency prediction. The results of the first phase - systematic evaluation of 16 test methods - are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data, potential for throughput, transferability and accessibility in cooperation with the test method developers. A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy - combined with bioavailability and skin metabolism data and exposure consideration - is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients.},
  author       = {Reisinger, Kerstin and Hoffmann, Sebastian and Alépée, Nathalie and Ashikaga, Takao and Barroso, Joao and Elcombe, Cliff and Gellatly, Nicola and Galbiati, Valentina and Gibbs, Susan and Groux, Hervé and Hibatallah, Jalila and Keller, Donald and Kern, Petra and Klaric, Martina and Kolle, Susanne and Kuehnl, Jochen and Lambrechts, Nathalie and Lindstedt, Malin and Millet, Marion and Martinozzi-Teissier, Silvia and Natsch, Andreas and Petersohn, Dirk and Pike, Ian and Sakaguchi, Hitoshi and Schepky, Andreas and Tailhardat, Magalie and Templier, Marie and van Vliet, Erwin and Maxwell, Gavin},
  issn         = {1879-3177},
  language     = {eng},
  number       = {1},
  pages        = {259--270},
  publisher    = {Elsevier},
  series       = {Toxicology in Vitro},
  title        = {Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.},
  url          = {http://dx.doi.org/10.1016/j.tiv.2014.10.018},
  volume       = {29},
  year         = {2015},
}