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Spinal cord stimulation alleviates motor deficits in a primate model of Parkinson disease.

Santana, Maxwell B; Halje, Pär LU ; Simplício, Hougelle; Richter, Ulrike LU ; Freire, Marco Aurelio M; Petersson, Per LU ; Fuentes, Romulo and Nicolelis, Miguel A L (2014) In Neuron 84(4). p.716-722
Abstract
Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method-epidural spinal cord stimulation (SCS)-has been suggested as an alternative approach for symptomatic treatment of PD. However, the mechanisms underlying motor improvements through SCS are unknown. Here, we show that SCS reproducibly alleviates motor deficits in a primate model of PD. Simultaneous neuronal recordings from multiple structures of the cortico-basal ganglia-thalamic loop in parkinsonian monkeys revealed abnormal highly synchronized neuronal activity within each of these structures and... (More)
Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method-epidural spinal cord stimulation (SCS)-has been suggested as an alternative approach for symptomatic treatment of PD. However, the mechanisms underlying motor improvements through SCS are unknown. Here, we show that SCS reproducibly alleviates motor deficits in a primate model of PD. Simultaneous neuronal recordings from multiple structures of the cortico-basal ganglia-thalamic loop in parkinsonian monkeys revealed abnormal highly synchronized neuronal activity within each of these structures and excessive functional coupling among them. SCS disrupted this pathological circuit behavior in a manner that mimics the effects caused by pharmacological dopamine replacement therapy or deep brain stimulation. These results suggest that SCS should be considered as an additional treatment option for patients with PD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuron
volume
84
issue
4
pages
716 - 722
publisher
Cell Press
external identifiers
  • pmid:25447740
  • wos:000345424900009
  • scopus:84918784799
ISSN
0896-6273
DOI
10.1016/j.neuron.2014.08.061
language
English
LU publication?
yes
id
224b1ad9-bac7-4841-8180-258d7072164e (old id 4913353)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25447740?dopt=Abstract
date added to LUP
2015-01-06 10:56:26
date last changed
2017-08-13 03:12:15
@article{224b1ad9-bac7-4841-8180-258d7072164e,
  abstract     = {Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method-epidural spinal cord stimulation (SCS)-has been suggested as an alternative approach for symptomatic treatment of PD. However, the mechanisms underlying motor improvements through SCS are unknown. Here, we show that SCS reproducibly alleviates motor deficits in a primate model of PD. Simultaneous neuronal recordings from multiple structures of the cortico-basal ganglia-thalamic loop in parkinsonian monkeys revealed abnormal highly synchronized neuronal activity within each of these structures and excessive functional coupling among them. SCS disrupted this pathological circuit behavior in a manner that mimics the effects caused by pharmacological dopamine replacement therapy or deep brain stimulation. These results suggest that SCS should be considered as an additional treatment option for patients with PD.},
  author       = {Santana, Maxwell B and Halje, Pär and Simplício, Hougelle and Richter, Ulrike and Freire, Marco Aurelio M and Petersson, Per and Fuentes, Romulo and Nicolelis, Miguel A L},
  issn         = {0896-6273},
  language     = {eng},
  number       = {4},
  pages        = {716--722},
  publisher    = {Cell Press},
  series       = {Neuron},
  title        = {Spinal cord stimulation alleviates motor deficits in a primate model of Parkinson disease.},
  url          = {http://dx.doi.org/10.1016/j.neuron.2014.08.061},
  volume       = {84},
  year         = {2014},
}