Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study
(2015) In Diabetologia 58(11). p.2525-2532- Abstract
- Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. Methods We used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes. Results Low birthweight increased the risk of LADA as well as the... (More)
- Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. Methods We used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes. Results Low birthweight increased the risk of LADA as well as the risk of type 2 diabetes; OR per kg reduction was estimated as 1.52 (95% CI 1.12, 2.08) and 1.58 (1.23, 2.04), respectively. The OR for participants weighing < 3 kg compared with >= 4 kg at birth was estimated as 2.38 (1.23, 4.60) for LADA and 2.37 (1.37, 4.10) for type 2 diabetes. A combination of low birthweight (< 3 kg) and current overweight (BMI >= 25) further augmented the risk: LADA, OR 3.26 (1.69, 6.29); and type 2 diabetes, OR 39.93 (19.27, 82.71). Family history of diabetes had little impact on these estimates. Conclusions/interpretation Our results suggest that low birthweight may be a risk factor for LADA of the same strength as for type 2 diabetes. These findings support LADA, despite its autoimmune component, having an aetiology that includes factors related to type 2 diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8220880
- author
- Hjort, Rebecka ; Alfredsson, Lars ; Carlsson, Per-Ola ; Groop, Leif LU ; Martinell, Mats ; Storm, Petter LU ; Tuomi, Tiinamaija and Carlsson, Sofia
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Birthweight, BMI, Case-control study, Interaction, LADA, Latent, autoimmune diabetes in adults, Type 2 diabetes
- in
- Diabetologia
- volume
- 58
- issue
- 11
- pages
- 2525 - 2532
- publisher
- Springer
- external identifiers
-
- wos:000361993000009
- scopus:84942991167
- pmid:26208603
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-015-3711-8
- language
- English
- LU publication?
- yes
- id
- 4915c8fe-1412-459d-8a90-be5c3b642bb6 (old id 8220880)
- date added to LUP
- 2016-04-01 10:02:33
- date last changed
- 2024-04-06 23:41:47
@article{4915c8fe-1412-459d-8a90-be5c3b642bb6, abstract = {{Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. Methods We used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes. Results Low birthweight increased the risk of LADA as well as the risk of type 2 diabetes; OR per kg reduction was estimated as 1.52 (95% CI 1.12, 2.08) and 1.58 (1.23, 2.04), respectively. The OR for participants weighing < 3 kg compared with >= 4 kg at birth was estimated as 2.38 (1.23, 4.60) for LADA and 2.37 (1.37, 4.10) for type 2 diabetes. A combination of low birthweight (< 3 kg) and current overweight (BMI >= 25) further augmented the risk: LADA, OR 3.26 (1.69, 6.29); and type 2 diabetes, OR 39.93 (19.27, 82.71). Family history of diabetes had little impact on these estimates. Conclusions/interpretation Our results suggest that low birthweight may be a risk factor for LADA of the same strength as for type 2 diabetes. These findings support LADA, despite its autoimmune component, having an aetiology that includes factors related to type 2 diabetes.}}, author = {{Hjort, Rebecka and Alfredsson, Lars and Carlsson, Per-Ola and Groop, Leif and Martinell, Mats and Storm, Petter and Tuomi, Tiinamaija and Carlsson, Sofia}}, issn = {{1432-0428}}, keywords = {{Birthweight; BMI; Case-control study; Interaction; LADA; Latent; autoimmune diabetes in adults; Type 2 diabetes}}, language = {{eng}}, number = {{11}}, pages = {{2525--2532}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study}}, url = {{http://dx.doi.org/10.1007/s00125-015-3711-8}}, doi = {{10.1007/s00125-015-3711-8}}, volume = {{58}}, year = {{2015}}, }