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Contribution of pre-synaptic mechanisms to l-DOPA-induced dyskinesia.

Carta, Manolo LU and Bezard, E (2011) In Neuroscience 198. p.245-251
Abstract
Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic l-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key role in the induction of dyskinesia. In this article we review the evidences pointing to the serotonin system as the primary cause for the abnormally high levels of l-DOPA-derived extracellular DA in Parkinson's disease, and we discuss the feasibility of a therapeutic approach targeting this system.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscience
volume
198
pages
245 - 251
publisher
Elsevier
external identifiers
  • wos:000297483700018
  • pmid:21840375
  • scopus:81255188854
  • pmid:21840375
ISSN
1873-7544
DOI
10.1016/j.neuroscience.2011.07.070
language
English
LU publication?
yes
id
492dd768-82a2-4597-980b-b8c449b51f1c (old id 2151091)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21840375?dopt=Abstract
date added to LUP
2016-04-04 07:28:59
date last changed
2020-02-12 07:42:31
@article{492dd768-82a2-4597-980b-b8c449b51f1c,
  abstract     = {Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic l-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key role in the induction of dyskinesia. In this article we review the evidences pointing to the serotonin system as the primary cause for the abnormally high levels of l-DOPA-derived extracellular DA in Parkinson's disease, and we discuss the feasibility of a therapeutic approach targeting this system.},
  author       = {Carta, Manolo and Bezard, E},
  issn         = {1873-7544},
  language     = {eng},
  pages        = {245--251},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Contribution of pre-synaptic mechanisms to l-DOPA-induced dyskinesia.},
  url          = {http://dx.doi.org/10.1016/j.neuroscience.2011.07.070},
  doi          = {10.1016/j.neuroscience.2011.07.070},
  volume       = {198},
  year         = {2011},
}