Contribution of pre-synaptic mechanisms to l-DOPA-induced dyskinesia.
(2011) In Neuroscience 198. p.245-251- Abstract
- Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic l-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key role in the induction of dyskinesia. In this article we review the evidences pointing to the serotonin system as the primary cause for the abnormally high levels of l-DOPA-derived extracellular DA in Parkinson's disease, and we discuss the feasibility of a therapeutic approach targeting this system.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2151091
- author
- Carta, Manolo LU and Bezard, E
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuroscience
- volume
- 198
- pages
- 245 - 251
- publisher
- Elsevier
- external identifiers
-
- wos:000297483700018
- pmid:21840375
- scopus:81255188854
- pmid:21840375
- ISSN
- 1873-7544
- DOI
- 10.1016/j.neuroscience.2011.07.070
- language
- English
- LU publication?
- yes
- id
- 492dd768-82a2-4597-980b-b8c449b51f1c (old id 2151091)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21840375?dopt=Abstract
- date added to LUP
- 2016-04-04 07:28:59
- date last changed
- 2025-04-04 15:01:12
@article{492dd768-82a2-4597-980b-b8c449b51f1c,
abstract = {{Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic l-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key role in the induction of dyskinesia. In this article we review the evidences pointing to the serotonin system as the primary cause for the abnormally high levels of l-DOPA-derived extracellular DA in Parkinson's disease, and we discuss the feasibility of a therapeutic approach targeting this system.}},
author = {{Carta, Manolo and Bezard, E}},
issn = {{1873-7544}},
language = {{eng}},
pages = {{245--251}},
publisher = {{Elsevier}},
series = {{Neuroscience}},
title = {{Contribution of pre-synaptic mechanisms to l-DOPA-induced dyskinesia.}},
url = {{http://dx.doi.org/10.1016/j.neuroscience.2011.07.070}},
doi = {{10.1016/j.neuroscience.2011.07.070}},
volume = {{198}},
year = {{2011}},
}