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Effects of organic solvents on motor activity in mice

Kjellstrand, Per; Holmquist, Björn LU ; Jonsson, I; Romare, Sören and Månsson, Lennart (1985) In Toxicology 35(1). p.35-46
Abstract
Groups of male mice were exposed via inhalation to methylene chloride, perchloroethylene, toluene, trichloroethylene or 1,1,1-trichloroethane. The exposures were started at 2300 h. Generation of vapor was stopped after 1 h. Motor activity of the animals during the exposures was measured with a Doppler radar. Several concentrations of each solvent were tested. Concentrations could be found for all solvents at which they initially increased the motor activity. When the generation of vapor was terminated and the concentration started to decline, a new phase of changes in motor activity was induced. At this phase, motor activity was in most cases influence in the opposite direction to that at the beginning of the exposure. Trichloroethylene... (More)
Groups of male mice were exposed via inhalation to methylene chloride, perchloroethylene, toluene, trichloroethylene or 1,1,1-trichloroethane. The exposures were started at 2300 h. Generation of vapor was stopped after 1 h. Motor activity of the animals during the exposures was measured with a Doppler radar. Several concentrations of each solvent were tested. Concentrations could be found for all solvents at which they initially increased the motor activity. When the generation of vapor was terminated and the concentration started to decline, a new phase of changes in motor activity was induced. At this phase, motor activity was in most cases influence in the opposite direction to that at the beginning of the exposure. Trichloroethylene concentrations could be found which gave no increase in activity at the start of exposure but a prominent decrease at termination. The lowest concentration at which effects could be seen was different for the different solvents. Perchloroethylene was more and 1,1,1-trichloroethane less potent than the other solvents in inducing motor activity. The time pattern of the motor activity alterations was specific for each solvent. Both the concentration and the rate of the concentration increase were responsible for the effects on motor activity. The differences between the solvents probably reflect differences in their site of action, their distribution and their biotransformation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Toxicology
volume
35
issue
1
pages
35 - 46
publisher
Elsevier
external identifiers
  • scopus:0021958580
ISSN
0300-483X
DOI
10.1016/0300-483X(85)90130-1
language
English
LU publication?
yes
id
1a7c5073-0339-4864-a62a-e9ffa771b9aa (old id 4934126)
date added to LUP
2015-01-20 16:45:14
date last changed
2017-04-30 14:27:29
@article{1a7c5073-0339-4864-a62a-e9ffa771b9aa,
  abstract     = {Groups of male mice were exposed via inhalation to methylene chloride, perchloroethylene, toluene, trichloroethylene or 1,1,1-trichloroethane. The exposures were started at 2300 h. Generation of vapor was stopped after 1 h. Motor activity of the animals during the exposures was measured with a Doppler radar. Several concentrations of each solvent were tested. Concentrations could be found for all solvents at which they initially increased the motor activity. When the generation of vapor was terminated and the concentration started to decline, a new phase of changes in motor activity was induced. At this phase, motor activity was in most cases influence in the opposite direction to that at the beginning of the exposure. Trichloroethylene concentrations could be found which gave no increase in activity at the start of exposure but a prominent decrease at termination. The lowest concentration at which effects could be seen was different for the different solvents. Perchloroethylene was more and 1,1,1-trichloroethane less potent than the other solvents in inducing motor activity. The time pattern of the motor activity alterations was specific for each solvent. Both the concentration and the rate of the concentration increase were responsible for the effects on motor activity. The differences between the solvents probably reflect differences in their site of action, their distribution and their biotransformation.},
  author       = {Kjellstrand, Per and Holmquist, Björn and Jonsson, I and Romare, Sören and Månsson, Lennart},
  issn         = {0300-483X},
  language     = {eng},
  number       = {1},
  pages        = {35--46},
  publisher    = {Elsevier},
  series       = {Toxicology},
  title        = {Effects of organic solvents on motor activity in mice},
  url          = {http://dx.doi.org/10.1016/0300-483X(85)90130-1},
  volume       = {35},
  year         = {1985},
}