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Trichloroethylene: Further studies of the effect on body and organ weights and plasma buturylcholinesterase activity in mice

Kjellstrand, Per; Holmquist, Björn LU ; Alm, P; Kanje, Martin LU ; Romare, Sören; Jonsson, I; Månsson, Lennart and Bjerkemo, M (1983) In Acta Pharmacologica et Toxicologica 53(5). p.375-384
Abstract
The effects of continuous and intermittent inhalation of trichloroethylene (TCE) were studied in male and female mice. Plasma butyrylcholinesterase (BuChE) activity, body, liver, kidney and spleen weights were measured. The liver was studied histologically and motor activity measured with doppler radar. Continuous TCE-exposure (37–300 p.p.m.) increased plasma BuChE activity in the males in a time and concentration dependent manner. After 30 days at 37 p.p.m. the increase was about 25%. Exposure to 300 p.p.m. for 30 days increased the activity three times. BuChE activity in females was only slightly influenced even at 300 p.p.m. Liver weight was increased in a time and concentration dependent manner in both sexes. In animals continuously... (More)
The effects of continuous and intermittent inhalation of trichloroethylene (TCE) were studied in male and female mice. Plasma butyrylcholinesterase (BuChE) activity, body, liver, kidney and spleen weights were measured. The liver was studied histologically and motor activity measured with doppler radar. Continuous TCE-exposure (37–300 p.p.m.) increased plasma BuChE activity in the males in a time and concentration dependent manner. After 30 days at 37 p.p.m. the increase was about 25%. Exposure to 300 p.p.m. for 30 days increased the activity three times. BuChE activity in females was only slightly influenced even at 300 p.p.m. Liver weight was increased in a time and concentration dependent manner in both sexes. In animals continuously exposed for 30 days to 300 p.p.m., liver weight was roughly twice that of the air-exposed controls. Morphological changes were observed in the liver of TCE-exposed animals. Above 150 p.p.m. kidney weight in both sexes was significantly increased. This effect was more pronounced in the males than in the females. Spleen weight was not influenced by the exposure. Body weight increase was slightly lower in exposed animals. Plasma BuChE activity and liver weight returned to normal when exposure was terminated. Intermittent exposure to short pulses of high concentration of TCE had roughly the same effect on BuChE, body and organ weights as continuous exposure to the same time-weighted average. Motor activity was affected by the intermittent exposure schedules. At 900 p.p.m. decrease in activity was observed. At 3600 p.p.m. motor activity was considerably increased. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Acta Pharmacologica et Toxicologica
volume
53
issue
5
pages
375 - 384
publisher
Nordic Pharmacological Society
external identifiers
  • scopus:0021023258
ISSN
0001-6683
DOI
10.1111/j.1600-0773.1983.tb03438.x
language
English
LU publication?
yes
id
28afc728-7917-41a4-93f2-a92bb54a101c (old id 4934696)
date added to LUP
2015-01-21 10:51:57
date last changed
2017-07-30 04:35:42
@article{28afc728-7917-41a4-93f2-a92bb54a101c,
  abstract     = {The effects of continuous and intermittent inhalation of trichloroethylene (TCE) were studied in male and female mice. Plasma butyrylcholinesterase (BuChE) activity, body, liver, kidney and spleen weights were measured. The liver was studied histologically and motor activity measured with doppler radar. Continuous TCE-exposure (37–300 p.p.m.) increased plasma BuChE activity in the males in a time and concentration dependent manner. After 30 days at 37 p.p.m. the increase was about 25%. Exposure to 300 p.p.m. for 30 days increased the activity three times. BuChE activity in females was only slightly influenced even at 300 p.p.m. Liver weight was increased in a time and concentration dependent manner in both sexes. In animals continuously exposed for 30 days to 300 p.p.m., liver weight was roughly twice that of the air-exposed controls. Morphological changes were observed in the liver of TCE-exposed animals. Above 150 p.p.m. kidney weight in both sexes was significantly increased. This effect was more pronounced in the males than in the females. Spleen weight was not influenced by the exposure. Body weight increase was slightly lower in exposed animals. Plasma BuChE activity and liver weight returned to normal when exposure was terminated. Intermittent exposure to short pulses of high concentration of TCE had roughly the same effect on BuChE, body and organ weights as continuous exposure to the same time-weighted average. Motor activity was affected by the intermittent exposure schedules. At 900 p.p.m. decrease in activity was observed. At 3600 p.p.m. motor activity was considerably increased.},
  author       = {Kjellstrand, Per and Holmquist, Björn and Alm, P and Kanje, Martin and Romare, Sören and Jonsson, I and Månsson, Lennart and Bjerkemo, M},
  issn         = {0001-6683},
  language     = {eng},
  number       = {5},
  pages        = {375--384},
  publisher    = {Nordic Pharmacological Society},
  series       = {Acta Pharmacologica et Toxicologica},
  title        = {Trichloroethylene: Further studies of the effect on body and organ weights and plasma buturylcholinesterase activity in mice},
  url          = {http://dx.doi.org/10.1111/j.1600-0773.1983.tb03438.x},
  volume       = {53},
  year         = {1983},
}