Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain
(1982) In Toxicology Letters 10(1). p.1-5- Abstract
- Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4934732
- author
- Kjellstrand, Per ; Edström, Anders LU ; Bjerkemo, M and Holmquist, Björn LU
- organization
- publishing date
- 1982
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ACPase, acid phosphatase, ANOVA, analysis of variance, CNS, central nervous system, TCE, trichloroethylene
- in
- Toxicology Letters
- volume
- 10
- issue
- 1
- pages
- 1 - 5
- publisher
- Elsevier
- external identifiers
-
- scopus:0020078238
- ISSN
- 1879-3169
- DOI
- 10.1016/0378-4274(82)90258-2
- language
- English
- LU publication?
- yes
- id
- 63760ef9-81cc-44b1-aed5-3d15911b0032 (old id 4934732)
- date added to LUP
- 2016-04-01 15:25:08
- date last changed
- 2021-01-03 04:48:58
@article{63760ef9-81cc-44b1-aed5-3d15911b0032, abstract = {{Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.}}, author = {{Kjellstrand, Per and Edström, Anders and Bjerkemo, M and Holmquist, Björn}}, issn = {{1879-3169}}, keywords = {{ACPase; acid phosphatase; ANOVA; analysis of variance; CNS; central nervous system; TCE; trichloroethylene}}, language = {{eng}}, number = {{1}}, pages = {{1--5}}, publisher = {{Elsevier}}, series = {{Toxicology Letters}}, title = {{Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain}}, url = {{http://dx.doi.org/10.1016/0378-4274(82)90258-2}}, doi = {{10.1016/0378-4274(82)90258-2}}, volume = {{10}}, year = {{1982}}, }