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Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain

Kjellstrand, Per; Edström, Anders LU ; Bjerkemo, M and Holmquist, Björn LU (1982) In Toxicology Letters 10(1). p.1-5
Abstract
Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ACPase, acid phosphatase, ANOVA, analysis of variance, CNS, central nervous system, TCE, trichloroethylene
in
Toxicology Letters
volume
10
issue
1
pages
1 - 5
publisher
Elsevier
external identifiers
  • scopus:0020078238
ISSN
1879-3169
DOI
10.1016/0378-4274(82)90258-2
language
English
LU publication?
yes
id
63760ef9-81cc-44b1-aed5-3d15911b0032 (old id 4934732)
date added to LUP
2015-01-22 13:17:22
date last changed
2017-01-01 06:39:18
@article{63760ef9-81cc-44b1-aed5-3d15911b0032,
  abstract     = {Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.},
  author       = {Kjellstrand, Per and Edström, Anders and Bjerkemo, M and Holmquist, Björn},
  issn         = {1879-3169},
  keyword      = {ACPase,acid phosphatase,ANOVA,analysis of variance,CNS,central nervous system,TCE,trichloroethylene},
  language     = {eng},
  number       = {1},
  pages        = {1--5},
  publisher    = {Elsevier},
  series       = {Toxicology Letters},
  title        = {Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain},
  url          = {http://dx.doi.org/10.1016/0378-4274(82)90258-2},
  volume       = {10},
  year         = {1982},
}