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Sensitization to palladium in Europe

Muris, Joris; Goossens, An; Goncalo, Margarida; Bircher, Andreas J.; Gimenez-Arnau, Ana; Foti, Caterina; Bruze, Magnus LU ; Andersen, Klaus Ejner; Rustemeyer, Thomas and Feilzer, Albert J., et al. (2015) In Contact Dermatitis 72(1). p.11-19
Abstract
BackgroundRecently, sodium tetrachloropalladate (Na2PdCl4) was found to be a more sensitive palladium patch test allergen than palladium dichloride (PdCl2). ObjectivesTo determine the optimal test concentration of Na2PdCl4, to evaluate the prevalence of palladium sensitization with Na2PdCl4 and PdCl2, and to compare the results with nickel sensitization in a European multicentre study. Materials and methodsIn addition to the European or national baseline series including NiSO(4)6H(2)0 5% pet., consecutive patients were tested with PdCl2 and Na2PdCl4 2%, 3% and 4% pet. in eight European dermatology clinics. The age and sex distributions were also evaluated in patients sensitized to nickel and palladium. ResultsIn total, 1651 patients were... (More)
BackgroundRecently, sodium tetrachloropalladate (Na2PdCl4) was found to be a more sensitive palladium patch test allergen than palladium dichloride (PdCl2). ObjectivesTo determine the optimal test concentration of Na2PdCl4, to evaluate the prevalence of palladium sensitization with Na2PdCl4 and PdCl2, and to compare the results with nickel sensitization in a European multicentre study. Materials and methodsIn addition to the European or national baseline series including NiSO(4)6H(2)0 5% pet., consecutive patients were tested with PdCl2 and Na2PdCl4 2%, 3% and 4% pet. in eight European dermatology clinics. The age and sex distributions were also evaluated in patients sensitized to nickel and palladium. ResultsIn total, 1651 patients were tested. Relative to 3% Na2PdCl4, 4% Na2PdCl4 did not add any information. Two per cent Na2PdCl4 resulted in more doubtful reactions and showed suboptimal reactivity. The prevalence of palladium sensitization doubled with Na2PdCl4 and was similar to that of nickel. Interestingly, in contrast to nickel sensitization, palladium sensitization was not related to female sex. ConclusionsThree per cent Na2PdCl4 pet. is the most suitable patch test concentration. Sensitization to palladium is almost as prevalent as sensitization to nickel. The sex distribution is different between nickel-sensitized and palladium-sensitized patients, suggesting different sources of exposure. (Less)
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publication status
published
subject
keywords
allergic contact dermatitis, cross-reactivity, epidemiology, metals, nickel, oral disease, palladium
in
Contact Dermatitis
volume
72
issue
1
pages
11 - 19
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000346594700003
  • scopus:84919363698
ISSN
0105-1873
DOI
10.1111/cod.12295
language
English
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yes
id
64404219-58e9-46ec-9494-bc5758054d61 (old id 4941570)
date added to LUP
2015-02-03 07:07:27
date last changed
2017-07-09 03:21:04
@article{64404219-58e9-46ec-9494-bc5758054d61,
  abstract     = {BackgroundRecently, sodium tetrachloropalladate (Na2PdCl4) was found to be a more sensitive palladium patch test allergen than palladium dichloride (PdCl2). ObjectivesTo determine the optimal test concentration of Na2PdCl4, to evaluate the prevalence of palladium sensitization with Na2PdCl4 and PdCl2, and to compare the results with nickel sensitization in a European multicentre study. Materials and methodsIn addition to the European or national baseline series including NiSO(4)6H(2)0 5% pet., consecutive patients were tested with PdCl2 and Na2PdCl4 2%, 3% and 4% pet. in eight European dermatology clinics. The age and sex distributions were also evaluated in patients sensitized to nickel and palladium. ResultsIn total, 1651 patients were tested. Relative to 3% Na2PdCl4, 4% Na2PdCl4 did not add any information. Two per cent Na2PdCl4 resulted in more doubtful reactions and showed suboptimal reactivity. The prevalence of palladium sensitization doubled with Na2PdCl4 and was similar to that of nickel. Interestingly, in contrast to nickel sensitization, palladium sensitization was not related to female sex. ConclusionsThree per cent Na2PdCl4 pet. is the most suitable patch test concentration. Sensitization to palladium is almost as prevalent as sensitization to nickel. The sex distribution is different between nickel-sensitized and palladium-sensitized patients, suggesting different sources of exposure.},
  author       = {Muris, Joris and Goossens, An and Goncalo, Margarida and Bircher, Andreas J. and Gimenez-Arnau, Ana and Foti, Caterina and Bruze, Magnus and Andersen, Klaus Ejner and Rustemeyer, Thomas and Feilzer, Albert J. and Kleverlaan, Cornelis J.},
  issn         = {0105-1873},
  keyword      = {allergic contact dermatitis,cross-reactivity,epidemiology,metals,nickel,oral disease,palladium},
  language     = {eng},
  number       = {1},
  pages        = {11--19},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Sensitization to palladium in Europe},
  url          = {http://dx.doi.org/10.1111/cod.12295},
  volume       = {72},
  year         = {2015},
}