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Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies

Wesnes, Keith A.; Aarsland, Dag; Ballard, Clive and Londos, Elisabet LU (2015) In International Journal of Geriatric Psychiatry 30(1). p.46-54
Abstract
ObjectiveIn both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory. MethodsA randomised double-blind, placebo-controlled, 24-week three centre trial of memantine (20mg/day) was conducted in which tests of attention (simple and choice reaction time) and word recognition (immediate and delayed) from the CDR System were administered prior to dosing and again at 12 and 24weeks. Although other results from this study have been published, the data from the CDR System tests were not included and are presented... (More)
ObjectiveIn both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory. MethodsA randomised double-blind, placebo-controlled, 24-week three centre trial of memantine (20mg/day) was conducted in which tests of attention (simple and choice reaction time) and word recognition (immediate and delayed) from the CDR System were administered prior to dosing and again at 12 and 24weeks. Although other results from this study have been published, the data from the CDR System tests were not included and are presented here for the first time. ResultsData were available for 51 patients (21 DLB and 30 PDD). In both populations, memantine produced statistically significant medium to large effect sized improvements to choice reaction time, immediate and delayed word recognition. ConclusionsThese are the first substantial improvements on cognitive tests of attention and episodic recognition memory identified with memantine in either DLB or PDD. Copyright (c) 2014 John Wiley & Sons, Ltd. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
memantine, dementia with Lewy bodies, Parkinson's disease dementia, attention, episodic memory, CDR System, automated cognitive tests
in
International Journal of Geriatric Psychiatry
volume
30
issue
1
pages
46 - 54
publisher
John Wiley and Sons Ltd
external identifiers
  • wos:000346278300005
  • scopus:84918769295
ISSN
1099-1166
DOI
10.1002/gps.4109
language
English
LU publication?
yes
id
92249c70-8375-4d54-a275-ef5f2bc4dc9a (old id 4941593)
date added to LUP
2015-02-03 07:07:09
date last changed
2017-09-03 03:00:57
@article{92249c70-8375-4d54-a275-ef5f2bc4dc9a,
  abstract     = {ObjectiveIn both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory. MethodsA randomised double-blind, placebo-controlled, 24-week three centre trial of memantine (20mg/day) was conducted in which tests of attention (simple and choice reaction time) and word recognition (immediate and delayed) from the CDR System were administered prior to dosing and again at 12 and 24weeks. Although other results from this study have been published, the data from the CDR System tests were not included and are presented here for the first time. ResultsData were available for 51 patients (21 DLB and 30 PDD). In both populations, memantine produced statistically significant medium to large effect sized improvements to choice reaction time, immediate and delayed word recognition. ConclusionsThese are the first substantial improvements on cognitive tests of attention and episodic recognition memory identified with memantine in either DLB or PDD. Copyright (c) 2014 John Wiley & Sons, Ltd.},
  author       = {Wesnes, Keith A. and Aarsland, Dag and Ballard, Clive and Londos, Elisabet},
  issn         = {1099-1166},
  keyword      = {memantine,dementia with Lewy bodies,Parkinson's disease dementia,attention,episodic memory,CDR System,automated cognitive tests},
  language     = {eng},
  number       = {1},
  pages        = {46--54},
  publisher    = {John Wiley and Sons Ltd},
  series       = {International Journal of Geriatric Psychiatry},
  title        = {Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies},
  url          = {http://dx.doi.org/10.1002/gps.4109},
  volume       = {30},
  year         = {2015},
}