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Obesity and asthma: current knowledge and future needs

Sivapalan, Pradeesh; Diamant, Zuzana LU and Ulrik, Charlotte Suppli (2015) In Current Opinion in Pulmonary Medicine 21(1). p.80-85
Abstract
Purpose of review Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction. Recent findings Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies... (More)
Purpose of review Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction. Recent findings Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies indicate that even a modest weight reduction can improve clinical manifestations and outcome of asthma. Summary Compared with normal-weight patients, obese and overweight patients with asthma have poorer asthma control and respond less to corticosteroid therapy. Future studies focusing on the mechanism underlying both obesity and asthma including the obese-asthma phenotype are required to better characterize the link between the conditions and target the management of this patient group. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
asthma, asthma control, inflammation, mechanism, obesity, phenotype, quality of life
in
Current Opinion in Pulmonary Medicine
volume
21
issue
1
pages
80 - 85
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000345912400012
  • scopus:84918503168
ISSN
1531-6971
DOI
10.1097/MCP.0000000000000119
language
English
LU publication?
yes
id
61e468be-7199-467f-b176-6b45245ca1aa (old id 4950719)
date added to LUP
2015-02-03 07:05:26
date last changed
2017-07-09 03:25:24
@article{61e468be-7199-467f-b176-6b45245ca1aa,
  abstract     = {Purpose of review Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction. Recent findings Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies indicate that even a modest weight reduction can improve clinical manifestations and outcome of asthma. Summary Compared with normal-weight patients, obese and overweight patients with asthma have poorer asthma control and respond less to corticosteroid therapy. Future studies focusing on the mechanism underlying both obesity and asthma including the obese-asthma phenotype are required to better characterize the link between the conditions and target the management of this patient group.},
  author       = {Sivapalan, Pradeesh and Diamant, Zuzana and Ulrik, Charlotte Suppli},
  issn         = {1531-6971},
  keyword      = {asthma,asthma control,inflammation,mechanism,obesity,phenotype,quality of life},
  language     = {eng},
  number       = {1},
  pages        = {80--85},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Pulmonary Medicine},
  title        = {Obesity and asthma: current knowledge and future needs},
  url          = {http://dx.doi.org/10.1097/MCP.0000000000000119},
  volume       = {21},
  year         = {2015},
}