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Obesity attenuates gender differences in cardiovascular mortality

Song, Xin; Tabak, Adam G.; Zethelius, Bjoern; Yudkin, John S.; Soederberg, Stefan; Laatikainen, Tiina; Stehouwer, Coen D. A.; Dankner, Rachel; Jousilahti, Pekka and Onat, Altan, et al. (2014) In Cardiovascular Diabetology 13.
Abstract
Background: To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender. Methods: Data from 11 prospective cohorts from four European countries including 23 629 men and 21 965 women, aged 24 to 99 years, with a median follow-up of 7.9 years were analyzed. Hazards ratios (HR) for CVD mortality in relation to baseline body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were estimated using Cox proportional hazards models with age as the timescale. Results: Men had higher CVD mortality than women in all four BMI categories (<25.0, 25.0-29.9, 30.0-34.9 and >= 35.0 kg/m(2)). Compared with the lowest BMI category in women, multivariable adjusted HRs (95%... (More)
Background: To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender. Methods: Data from 11 prospective cohorts from four European countries including 23 629 men and 21 965 women, aged 24 to 99 years, with a median follow-up of 7.9 years were analyzed. Hazards ratios (HR) for CVD mortality in relation to baseline body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were estimated using Cox proportional hazards models with age as the timescale. Results: Men had higher CVD mortality than women in all four BMI categories (<25.0, 25.0-29.9, 30.0-34.9 and >= 35.0 kg/m(2)). Compared with the lowest BMI category in women, multivariable adjusted HRs (95% confidence intervals) for higher BMI categories are 1.0 (0.8-1.4), 1.6 (1.1-2.1) and 2.8 (2.0-3.8) in women and 2.8 (2.2-3.6), 3.1 (2.5-3.9), 3.8 (2.9-4.9) and 5.4 (3.8-7.7) in men, respectively. Similar findings were observed for abdominal obesity defined by WC, WHR or WHtR. The gender difference was slightly smaller in obese than in non-obese individuals; but the interaction was statistically significant only between gender and WC (p = 0.02), and WHtR (p = 0.01). None of the interaction terms was significant among non-diabetic individuals. Conclusions: Men had higher CVD mortality than women across categories of anthropometric measures of obesity. The gender difference was attenuated in obese individuals, which warrants further investigation. (Less)
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keywords
Obesity, Gender, Cardiovascular disease mortality
in
Cardiovascular Diabetology
volume
13
publisher
BioMed Central
external identifiers
  • wos:000346062200001
  • scopus:84964315277
ISSN
1475-2840
DOI
10.1186/s12933-014-0144-5
language
English
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yes
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87021fee-74ad-4410-8361-915abc6a6209 (old id 4965704)
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2015-02-03 07:02:59
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2017-04-09 03:58:28
@article{87021fee-74ad-4410-8361-915abc6a6209,
  abstract     = {Background: To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender. Methods: Data from 11 prospective cohorts from four European countries including 23 629 men and 21 965 women, aged 24 to 99 years, with a median follow-up of 7.9 years were analyzed. Hazards ratios (HR) for CVD mortality in relation to baseline body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were estimated using Cox proportional hazards models with age as the timescale. Results: Men had higher CVD mortality than women in all four BMI categories (&lt;25.0, 25.0-29.9, 30.0-34.9 and &gt;= 35.0 kg/m(2)). Compared with the lowest BMI category in women, multivariable adjusted HRs (95% confidence intervals) for higher BMI categories are 1.0 (0.8-1.4), 1.6 (1.1-2.1) and 2.8 (2.0-3.8) in women and 2.8 (2.2-3.6), 3.1 (2.5-3.9), 3.8 (2.9-4.9) and 5.4 (3.8-7.7) in men, respectively. Similar findings were observed for abdominal obesity defined by WC, WHR or WHtR. The gender difference was slightly smaller in obese than in non-obese individuals; but the interaction was statistically significant only between gender and WC (p = 0.02), and WHtR (p = 0.01). None of the interaction terms was significant among non-diabetic individuals. Conclusions: Men had higher CVD mortality than women across categories of anthropometric measures of obesity. The gender difference was attenuated in obese individuals, which warrants further investigation.},
  articleno    = {144},
  author       = {Song, Xin and Tabak, Adam G. and Zethelius, Bjoern and Yudkin, John S. and Soederberg, Stefan and Laatikainen, Tiina and Stehouwer, Coen D. A. and Dankner, Rachel and Jousilahti, Pekka and Onat, Altan and Nilsson, Peter and Satman, Ilhan and Vaccaro, Olga and Tuomilehto, Jaakko and Qiao, Qing},
  issn         = {1475-2840},
  keyword      = {Obesity,Gender,Cardiovascular disease mortality},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Cardiovascular Diabetology},
  title        = {Obesity attenuates gender differences in cardiovascular mortality},
  url          = {http://dx.doi.org/10.1186/s12933-014-0144-5},
  volume       = {13},
  year         = {2014},
}