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Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist

Wieloch, Tadeusz LU (1985) In Science 230(4726). p.681-683
Abstract

The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
230
issue
4726
pages
3 pages
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • pmid:2996146
  • scopus:0022344980
ISSN
0036-8075
DOI
10.1126/science.2996146
language
English
LU publication?
yes
id
4974837b-f849-4ea8-9fb9-9705b16ec771
date added to LUP
2019-06-13 17:48:00
date last changed
2024-04-02 07:59:52
@article{4974837b-f849-4ea8-9fb9-9705b16ec771,
  abstract     = {{<p>The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.</p>}},
  author       = {{Wieloch, Tadeusz}},
  issn         = {{0036-8075}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4726}},
  pages        = {{681--683}},
  publisher    = {{American Association for the Advancement of Science (AAAS)}},
  series       = {{Science}},
  title        = {{Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist}},
  url          = {{http://dx.doi.org/10.1126/science.2996146}},
  doi          = {{10.1126/science.2996146}},
  volume       = {{230}},
  year         = {{1985}},
}