Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist
(1985) In Science 230(4726). p.681-683- Abstract
The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4974837b-f849-4ea8-9fb9-9705b16ec771
- author
- Wieloch, Tadeusz LU
- organization
- publishing date
- 1985-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 230
- issue
- 4726
- pages
- 3 pages
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:2996146
- scopus:0022344980
- ISSN
- 0036-8075
- DOI
- 10.1126/science.2996146
- language
- English
- LU publication?
- yes
- id
- 4974837b-f849-4ea8-9fb9-9705b16ec771
- date added to LUP
- 2019-06-13 17:48:00
- date last changed
- 2024-09-19 01:09:56
@article{4974837b-f849-4ea8-9fb9-9705b16ec771, abstract = {{<p>The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.</p>}}, author = {{Wieloch, Tadeusz}}, issn = {{0036-8075}}, language = {{eng}}, month = {{01}}, number = {{4726}}, pages = {{681--683}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science}}, title = {{Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist}}, url = {{http://dx.doi.org/10.1126/science.2996146}}, doi = {{10.1126/science.2996146}}, volume = {{230}}, year = {{1985}}, }