Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor Microenvironment
Kuras, Magdalena LU
(2023)
In International Journal of Molecular Sciences
24(18).
- Abstract
Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous nature and high metastatic potential. The incidence of melanoma is continuously increasing worldwide, and it is one of the most common cancers in young adults. In the past twenty years, our understanding of melanoma biology has increased profoundly, and disease management for patients with disseminated disease has improved due to the emergence of immunotherapy and targeted therapy. However, a significant fraction of patients relapse or do not respond adequately to treatment. This can partly be explained by the complex signaling between the tumor and its microenvironment, giving rise to melanoma phenotypes with different patterns of disease progression.... (More)
Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous nature and high metastatic potential. The incidence of melanoma is continuously increasing worldwide, and it is one of the most common cancers in young adults. In the past twenty years, our understanding of melanoma biology has increased profoundly, and disease management for patients with disseminated disease has improved due to the emergence of immunotherapy and targeted therapy. However, a significant fraction of patients relapse or do not respond adequately to treatment. This can partly be explained by the complex signaling between the tumor and its microenvironment, giving rise to melanoma phenotypes with different patterns of disease progression. This review focuses on the key aspects and complex relationship between pathogenesis, genetic abnormalities, tumor microenvironment, cellular plasticity, and metabolic reprogramming in melanoma. By acquiring a deeper understanding of the multifaceted features of melanomagenesis, we can reach a point of more individualized and patient-centered disease management and reduced costs of ineffective treatments.
(Less)
- author
- Kuras, Magdalena
LU
- organization
- publishing date
- 2023-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cellular plasticity, malignant melanoma, metabolic reprogramming, molecular classifications, mutational burden, phenotype switching, treatment resistance, tumor microenvironment
- in
- International Journal of Molecular Sciences
- volume
- 24
- issue
- 18
- article number
- 14403
- publisher
- MDPI AG
- external identifiers
-
- pmid:37762707
- scopus:85173020258
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms241814403
- language
- English
- LU publication?
- yes
- id
- 497d3a96-a0f4-4257-a6ac-03e64a38e836
- date added to LUP
- 2023-12-18 09:49:34
- date last changed
- 2024-04-16 22:00:58
@article{497d3a96-a0f4-4257-a6ac-03e64a38e836,
abstract = {{<p>Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous nature and high metastatic potential. The incidence of melanoma is continuously increasing worldwide, and it is one of the most common cancers in young adults. In the past twenty years, our understanding of melanoma biology has increased profoundly, and disease management for patients with disseminated disease has improved due to the emergence of immunotherapy and targeted therapy. However, a significant fraction of patients relapse or do not respond adequately to treatment. This can partly be explained by the complex signaling between the tumor and its microenvironment, giving rise to melanoma phenotypes with different patterns of disease progression. This review focuses on the key aspects and complex relationship between pathogenesis, genetic abnormalities, tumor microenvironment, cellular plasticity, and metabolic reprogramming in melanoma. By acquiring a deeper understanding of the multifaceted features of melanomagenesis, we can reach a point of more individualized and patient-centered disease management and reduced costs of ineffective treatments.</p>}},
author = {{Kuras, Magdalena}},
issn = {{1661-6596}},
keywords = {{cellular plasticity; malignant melanoma; metabolic reprogramming; molecular classifications; mutational burden; phenotype switching; treatment resistance; tumor microenvironment}},
language = {{eng}},
number = {{18}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor Microenvironment}},
url = {{http://dx.doi.org/10.3390/ijms241814403}},
doi = {{10.3390/ijms241814403}},
volume = {{24}},
year = {{2023}},
}