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Duration of disease does not equally influence all aspects of quality of life in Parkinson's disease

Benge, Jared F.; Kekecs, Zoltán LU ; Encarnacion, Elmyra; Ainslie, Melissa; Herff, Christina; Elkins, Gary and Herath, Priyantha (2016) In Journal of Clinical Neuroscience 28. p.102-106
Abstract

Health related quality of life (HRQoL) is negatively impacted in patients suffering from Parkinson's disease (PD). For the specific components that comprise HRQoL, the relationship between clinical variables, such as disease duration, is not fully characterized. In this cross-sectional study (n = 302), self-reported HRQoL on the Parkinson's Disease Questionnaire (PDQ-39) was evaluated as a global construct as well as individual subscale scores. HRQoL was compared in three groups: those within 5 years of diagnosis, those within 6-10 years of diagnosis, and those greater than 11 years since diagnosis. Non-parametric analyses revealed lower HRQoL with increasing disease duration when assessed as a global construct. However, when subscales... (More)

Health related quality of life (HRQoL) is negatively impacted in patients suffering from Parkinson's disease (PD). For the specific components that comprise HRQoL, the relationship between clinical variables, such as disease duration, is not fully characterized. In this cross-sectional study (n = 302), self-reported HRQoL on the Parkinson's Disease Questionnaire (PDQ-39) was evaluated as a global construct as well as individual subscale scores. HRQoL was compared in three groups: those within 5 years of diagnosis, those within 6-10 years of diagnosis, and those greater than 11 years since diagnosis. Non-parametric analyses revealed lower HRQoL with increasing disease duration when assessed as a global construct. However, when subscales were evaluated, difficulties with bodily discomfort and cognitive complaints were comparable in individuals in the 1-5 years and 6-10 year duration groups. Exploratory regression analyses suggested disease duration does explain unique variance in some subscales, even after controlling for Hoehn and Yahr stage and neuropsychiatric features. Our findings show that HRQoL domains in PD patients are affected differentially across the duration of the disease. Clinicians and researchers may need to tailor interventions intended to improve HRQoL at different domains as the disease progresses.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Disease duration, Health-related quality of life, Parkinson's disease
in
Journal of Clinical Neuroscience
volume
28
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:84954306811
ISSN
0967-5868
DOI
10.1016/j.jocn.2015.09.019
language
English
LU publication?
no
id
49d90150-2248-4f8b-83e4-c2ff0f69affe
date added to LUP
2017-03-27 15:49:07
date last changed
2017-04-12 11:27:08
@article{49d90150-2248-4f8b-83e4-c2ff0f69affe,
  abstract     = {<p>Health related quality of life (HRQoL) is negatively impacted in patients suffering from Parkinson's disease (PD). For the specific components that comprise HRQoL, the relationship between clinical variables, such as disease duration, is not fully characterized. In this cross-sectional study (n = 302), self-reported HRQoL on the Parkinson's Disease Questionnaire (PDQ-39) was evaluated as a global construct as well as individual subscale scores. HRQoL was compared in three groups: those within 5 years of diagnosis, those within 6-10 years of diagnosis, and those greater than 11 years since diagnosis. Non-parametric analyses revealed lower HRQoL with increasing disease duration when assessed as a global construct. However, when subscales were evaluated, difficulties with bodily discomfort and cognitive complaints were comparable in individuals in the 1-5 years and 6-10 year duration groups. Exploratory regression analyses suggested disease duration does explain unique variance in some subscales, even after controlling for Hoehn and Yahr stage and neuropsychiatric features. Our findings show that HRQoL domains in PD patients are affected differentially across the duration of the disease. Clinicians and researchers may need to tailor interventions intended to improve HRQoL at different domains as the disease progresses.</p>},
  author       = {Benge, Jared F. and Kekecs, Zoltán and Encarnacion, Elmyra and Ainslie, Melissa and Herff, Christina and Elkins, Gary and Herath, Priyantha},
  issn         = {0967-5868},
  keyword      = {Disease duration,Health-related quality of life,Parkinson's disease},
  language     = {eng},
  month        = {06},
  pages        = {102--106},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Neuroscience},
  title        = {Duration of disease does not equally influence all aspects of quality of life in Parkinson's disease},
  url          = {http://dx.doi.org/10.1016/j.jocn.2015.09.019},
  volume       = {28},
  year         = {2016},
}