Serine racemase modulation for improving brain insulin resistance : An Editorial Highlight for “Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers”
Duarte, João M.N. LU
(2022)
In Journal of Neurochemistry
163(1).
p.6-7
- Abstract
This Editorial highlights an interesting study in the current issue of the Journal of Neurochemistry in which Zhou et al. report new data showing that the ablation of serine racemase increases local insulin production in neurons of the hippocampus. The authors explored some of the possible mechanisms mediating the interaction between dampening production of D-serine and the local synthesis of insulin, and they further propose that stimulating insulin production could counteract hippocampal insulin resistance in Alzheimer's disease (AD). Most importantly, they leave open a number of questions that need to be experimentally addressed to ascertain whether D-serine modulation of neuronal insulin expression can effectively improve insulin... (More)
This Editorial highlights an interesting study in the current issue of the Journal of Neurochemistry in which Zhou et al. report new data showing that the ablation of serine racemase increases local insulin production in neurons of the hippocampus. The authors explored some of the possible mechanisms mediating the interaction between dampening production of D-serine and the local synthesis of insulin, and they further propose that stimulating insulin production could counteract hippocampal insulin resistance in Alzheimer's disease (AD). Most importantly, they leave open a number of questions that need to be experimentally addressed to ascertain whether D-serine modulation of neuronal insulin expression can effectively improve insulin sensitivity in AD, as well as in metabolic disease with neurological impact.
(Less)
- author
- Duarte, João M.N.
LU
- organization
- publishing date
- 2022-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzeimer's disease, D-serine, insulin, metabolism
- in
- Journal of Neurochemistry
- volume
- 163
- issue
- 1
- pages
- 6 - 7
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:35996309
- scopus:85136483318
- ISSN
- 0022-3042
- DOI
- 10.1111/jnc.15688
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2022 International Society for Neurochemistry.
- id
- 49e3dea0-2df0-4443-859b-ee841f0102d5
- date added to LUP
- 2024-01-08 10:54:15
- date last changed
- 2024-04-09 03:46:41
@misc{49e3dea0-2df0-4443-859b-ee841f0102d5,
abstract = {{<p>This Editorial highlights an interesting study in the current issue of the Journal of Neurochemistry in which Zhou et al. report new data showing that the ablation of serine racemase increases local insulin production in neurons of the hippocampus. The authors explored some of the possible mechanisms mediating the interaction between dampening production of D-serine and the local synthesis of insulin, and they further propose that stimulating insulin production could counteract hippocampal insulin resistance in Alzheimer's disease (AD). Most importantly, they leave open a number of questions that need to be experimentally addressed to ascertain whether D-serine modulation of neuronal insulin expression can effectively improve insulin sensitivity in AD, as well as in metabolic disease with neurological impact.</p>}},
author = {{Duarte, João M.N.}},
issn = {{0022-3042}},
keywords = {{Alzeimer's disease; D-serine; insulin; metabolism}},
language = {{eng}},
number = {{1}},
pages = {{6--7}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Neurochemistry}},
title = {{Serine racemase modulation for improving brain insulin resistance : An Editorial Highlight for “Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers”}},
url = {{http://dx.doi.org/10.1111/jnc.15688}},
doi = {{10.1111/jnc.15688}},
volume = {{163}},
year = {{2022}},
}