A non-random deletion in the p53 gene in oral squamous cell carcinoma
(1996) In British Journal of Cancer 73(11). p.1381-1386- Abstract
In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this... (More)
In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group.
(Less)
- author
- Nylander, K.
; Schildt, E. B.
LU
; Eriksson, M.
LU
; Magnusson, A. ; Mehle, C. and Roos, G. LU
- organization
- publishing date
- 1996-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Deletion, Epidemiology, Head and neck, p53 gene, Squamous cell carcinoma
- in
- British Journal of Cancer
- volume
- 73
- issue
- 11
- pages
- 1381 - 1386
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:0029886709
- pmid:8645583
- ISSN
- 0007-0920
- DOI
- 10.1038/bjc.1996.262
- language
- English
- LU publication?
- yes
- id
- 49e56649-dbbc-4b79-bb3d-58385d810d2b
- date added to LUP
- 2020-02-18 17:32:20
- date last changed
- 2024-01-02 05:52:32
@article{49e56649-dbbc-4b79-bb3d-58385d810d2b, abstract = {{<p>In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group.</p>}}, author = {{Nylander, K. and Schildt, E. B. and Eriksson, M. and Magnusson, A. and Mehle, C. and Roos, G.}}, issn = {{0007-0920}}, keywords = {{Deletion; Epidemiology; Head and neck; p53 gene; Squamous cell carcinoma}}, language = {{eng}}, month = {{01}}, number = {{11}}, pages = {{1381--1386}}, publisher = {{Nature Publishing Group}}, series = {{British Journal of Cancer}}, title = {{A non-random deletion in the p53 gene in oral squamous cell carcinoma}}, url = {{http://dx.doi.org/10.1038/bjc.1996.262}}, doi = {{10.1038/bjc.1996.262}}, volume = {{73}}, year = {{1996}}, }