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A non-random deletion in the p53 gene in oral squamous cell carcinoma

Nylander, K. ; Schildt, E. B. LU ; Eriksson, M. LU ; Magnusson, A. ; Mehle, C. and Roos, G. LU (1996) In British Journal of Cancer 73(11). p.1381-1386
Abstract

In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this... (More)

In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Deletion, Epidemiology, Head and neck, p53 gene, Squamous cell carcinoma
in
British Journal of Cancer
volume
73
issue
11
pages
1381 - 1386
publisher
Nature Publishing Group
external identifiers
  • scopus:0029886709
  • pmid:8645583
ISSN
0007-0920
DOI
10.1038/bjc.1996.262
language
English
LU publication?
yes
id
49e56649-dbbc-4b79-bb3d-58385d810d2b
date added to LUP
2020-02-18 17:32:20
date last changed
2021-01-06 04:08:07
@article{49e56649-dbbc-4b79-bb3d-58385d810d2b,
  abstract     = {<p>In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group.</p>},
  author       = {Nylander, K. and Schildt, E. B. and Eriksson, M. and Magnusson, A. and Mehle, C. and Roos, G.},
  issn         = {0007-0920},
  language     = {eng},
  month        = {01},
  number       = {11},
  pages        = {1381--1386},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {A non-random deletion in the p53 gene in oral squamous cell carcinoma},
  url          = {http://dx.doi.org/10.1038/bjc.1996.262},
  doi          = {10.1038/bjc.1996.262},
  volume       = {73},
  year         = {1996},
}