Tissue responses to novel tissue engineering biodegradable cryogel scaffolds: An animal model
(2009) In Journal of Biomedical Materials Research. Part A 91A(1). p.60-68- Abstract
- Biodegradable macroporous cryogels with highly open and interconnected pore structures were produced from dextran modified with oligo L-lactide bearing hydroxyethylmethacrylate (HEMA) end groups in moderately frozen solutions. Tissue responses to these novel scaffolds were evaluated in rats after dorsal subcutaneous implantation, iliac submuscular implantation, auricular implantation, or in calvarial defect model. In no case, either necrosis or foreign body reaction was observed during histological studies. The cryogel scaffolds integrated with the surrounding tissue and the formation of a new tissue were accompanied with significant ingrowth of connective tissue cells and new blood vessels into the cryogel. The tissue responses were... (More)
- Biodegradable macroporous cryogels with highly open and interconnected pore structures were produced from dextran modified with oligo L-lactide bearing hydroxyethylmethacrylate (HEMA) end groups in moderately frozen solutions. Tissue responses to these novel scaffolds were evaluated in rats after dorsal subcutaneous implantation, iliac submuscular implantation, auricular implantation, or in calvarial defect model. In no case, either necrosis or foreign body reaction was observed during histological studies. The cryogel scaffolds integrated with the surrounding tissue and the formation of a new tissue were accompanied with significant ingrowth of connective tissue cells and new blood vessels into the cryogel. The tissue responses were significantly lower in auricular and calvarial implantations when compared with the subcutanous and the submuscular implantations. The degradation of the scaffold was slower in bone comparing to soft tissues. The biodegradable cryogels are highly biocompatible and combine extraordinary properties including having soft and elastic nature, open porous structure, and very rapid and controllable swelling. Therefore, the cryogels could be promising candidates for further clinical applications in tissue regeneration. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91 A: 60-68, 2009 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1475171
- author
- Bolgen, Nimet ; Vargel, Ibrahim ; Korkusuz, Petek ; Guzel, Elif ; Plieva, Fatima ; Galaev, Igor LU ; Matiasson, Bo and Piskin, Erhan
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- HEMA-L-lactide-dextran, biodegradable, tissue-engineering scaffolds, cryogels, animal model, tissue reponses
- in
- Journal of Biomedical Materials Research. Part A
- volume
- 91A
- issue
- 1
- pages
- 60 - 68
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000269627700007
- scopus:70349113963
- ISSN
- 1552-4965
- DOI
- 10.1002/jbm.a.32193
- language
- English
- LU publication?
- yes
- id
- 4a067f6a-7a74-4b87-9046-d450790e0dde (old id 1475171)
- date added to LUP
- 2016-04-01 11:55:54
- date last changed
- 2022-02-18 07:25:02
@article{4a067f6a-7a74-4b87-9046-d450790e0dde,
abstract = {{Biodegradable macroporous cryogels with highly open and interconnected pore structures were produced from dextran modified with oligo L-lactide bearing hydroxyethylmethacrylate (HEMA) end groups in moderately frozen solutions. Tissue responses to these novel scaffolds were evaluated in rats after dorsal subcutaneous implantation, iliac submuscular implantation, auricular implantation, or in calvarial defect model. In no case, either necrosis or foreign body reaction was observed during histological studies. The cryogel scaffolds integrated with the surrounding tissue and the formation of a new tissue were accompanied with significant ingrowth of connective tissue cells and new blood vessels into the cryogel. The tissue responses were significantly lower in auricular and calvarial implantations when compared with the subcutanous and the submuscular implantations. The degradation of the scaffold was slower in bone comparing to soft tissues. The biodegradable cryogels are highly biocompatible and combine extraordinary properties including having soft and elastic nature, open porous structure, and very rapid and controllable swelling. Therefore, the cryogels could be promising candidates for further clinical applications in tissue regeneration. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91 A: 60-68, 2009}},
author = {{Bolgen, Nimet and Vargel, Ibrahim and Korkusuz, Petek and Guzel, Elif and Plieva, Fatima and Galaev, Igor and Matiasson, Bo and Piskin, Erhan}},
issn = {{1552-4965}},
keywords = {{HEMA-L-lactide-dextran; biodegradable; tissue-engineering scaffolds; cryogels; animal model; tissue reponses}},
language = {{eng}},
number = {{1}},
pages = {{60--68}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Biomedical Materials Research. Part A}},
title = {{Tissue responses to novel tissue engineering biodegradable cryogel scaffolds: An animal model}},
url = {{http://dx.doi.org/10.1002/jbm.a.32193}},
doi = {{10.1002/jbm.a.32193}},
volume = {{91A}},
year = {{2009}},
}