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Autoimmune pathogenesis and autoimmune hemolytic anemia

Semple, John W. LU and Freedman, John (2005) In Seminars in Hematology 42(3). p.122-130
Abstract

Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which autoantibodies are directed against an individual's own red blood cells (RBCs), leading to enhanced clearance through Fc receptor (FcR)-mediated phagocytosis. Although there is a large literature relating to clinical aspects of AIHA, relatively little work addresses how IgG autoantibodies are actually produced against RBC autoantigens. This review will first discuss the current understanding of autoimmunity in general and then focus on the knowledge of the immunopathogenic mechanisms responsible for autoantibody production in AIHA. Both human and animal studies will be discussed. Understanding theses mechanism is vital for developing antigen-specific immunotherapies... (More)

Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which autoantibodies are directed against an individual's own red blood cells (RBCs), leading to enhanced clearance through Fc receptor (FcR)-mediated phagocytosis. Although there is a large literature relating to clinical aspects of AIHA, relatively little work addresses how IgG autoantibodies are actually produced against RBC autoantigens. This review will first discuss the current understanding of autoimmunity in general and then focus on the knowledge of the immunopathogenic mechanisms responsible for autoantibody production in AIHA. Both human and animal studies will be discussed. Understanding theses mechanism is vital for developing antigen-specific immunotherapies to treat the disease.

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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Hematology
volume
42
issue
3
pages
122 - 130
publisher
Elsevier
external identifiers
  • scopus:22544453297
  • pmid:16041661
ISSN
0037-1963
DOI
10.1053/j.seminhematol.2005.04.002
language
English
LU publication?
no
id
4a130c2d-0871-47fe-a6b5-39803304b95e
date added to LUP
2019-12-03 10:21:06
date last changed
2020-05-24 06:28:06
@article{4a130c2d-0871-47fe-a6b5-39803304b95e,
  abstract     = {<p>Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which autoantibodies are directed against an individual's own red blood cells (RBCs), leading to enhanced clearance through Fc receptor (FcR)-mediated phagocytosis. Although there is a large literature relating to clinical aspects of AIHA, relatively little work addresses how IgG autoantibodies are actually produced against RBC autoantigens. This review will first discuss the current understanding of autoimmunity in general and then focus on the knowledge of the immunopathogenic mechanisms responsible for autoantibody production in AIHA. Both human and animal studies will be discussed. Understanding theses mechanism is vital for developing antigen-specific immunotherapies to treat the disease.</p>},
  author       = {Semple, John W. and Freedman, John},
  issn         = {0037-1963},
  language     = {eng},
  number       = {3},
  pages        = {122--130},
  publisher    = {Elsevier},
  series       = {Seminars in Hematology},
  title        = {Autoimmune pathogenesis and autoimmune hemolytic anemia},
  url          = {http://dx.doi.org/10.1053/j.seminhematol.2005.04.002},
  doi          = {10.1053/j.seminhematol.2005.04.002},
  volume       = {42},
  year         = {2005},
}