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Monitoring of seasonality of norovirus and other enteric viruses in Cameroon by real-time PCR : An exploratory study

Ayukekbong, J. A. ; Andersson, M. E. ; Vansarla, G. LU ; Tah, F. ; Nkuo-Akenji, T. ; Lindh, M. and Bergström, T. (2014) In Epidemiology and Infection 142(7). p.1393-1402
Abstract

We studied the seasonal fluctuation of norovirus and other enteric viruses in Cameroon. Two hundred participants aged between 1 and 69 years were prospectively followed up. Each participant provided monthly faecal samples over a 12-month period. A total of 2484 samples were tested using multiplex real-time PCR assay for the detection of norovirus, rotavirus and enterovirus. The effect of weather variables and risk factors were analysed by Pearson correlation and bivariate analysis. Overall, enterovirus was the most commonly detected virus (21·6% of specimens), followed by norovirus (3·9%) and rotavirus (0·4%). Norovirus and enterovirus were detected throughout the year with a peak of norovirus detection at the beginning of the rainy... (More)

We studied the seasonal fluctuation of norovirus and other enteric viruses in Cameroon. Two hundred participants aged between 1 and 69 years were prospectively followed up. Each participant provided monthly faecal samples over a 12-month period. A total of 2484 samples were tested using multiplex real-time PCR assay for the detection of norovirus, rotavirus and enterovirus. The effect of weather variables and risk factors were analysed by Pearson correlation and bivariate analysis. Overall, enterovirus was the most commonly detected virus (21·6% of specimens), followed by norovirus (3·9%) and rotavirus (0·4%). Norovirus and enterovirus were detected throughout the year with a peak of norovirus detection at the beginning of the rainy season and a significant alternation of circulation of norovirus genogroups from one month to the next. Age <5 years and consumption of tap water were risk factors for norovirus infection. Better understanding of factors influencing transmission and seasonality may provide insights into the relationship between physical environment and risk of infection for these viruses.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Enterovirus, epidemiology, Norwalk agent and related viruses, rotavirus, virus infection
in
Epidemiology and Infection
volume
142
issue
7
pages
10 pages
publisher
Cambridge University Press
external identifiers
  • scopus:84901423355
  • pmid:24047516
ISSN
0950-2688
DOI
10.1017/S095026881300232X
language
English
LU publication?
no
id
4a22cbc7-19b7-4bf4-b356-dcb638ef13ed
date added to LUP
2021-01-22 16:47:08
date last changed
2024-05-02 04:06:06
@article{4a22cbc7-19b7-4bf4-b356-dcb638ef13ed,
  abstract     = {{<p>We studied the seasonal fluctuation of norovirus and other enteric viruses in Cameroon. Two hundred participants aged between 1 and 69 years were prospectively followed up. Each participant provided monthly faecal samples over a 12-month period. A total of 2484 samples were tested using multiplex real-time PCR assay for the detection of norovirus, rotavirus and enterovirus. The effect of weather variables and risk factors were analysed by Pearson correlation and bivariate analysis. Overall, enterovirus was the most commonly detected virus (21·6% of specimens), followed by norovirus (3·9%) and rotavirus (0·4%). Norovirus and enterovirus were detected throughout the year with a peak of norovirus detection at the beginning of the rainy season and a significant alternation of circulation of norovirus genogroups from one month to the next. Age &lt;5 years and consumption of tap water were risk factors for norovirus infection. Better understanding of factors influencing transmission and seasonality may provide insights into the relationship between physical environment and risk of infection for these viruses.</p>}},
  author       = {{Ayukekbong, J. A. and Andersson, M. E. and Vansarla, G. and Tah, F. and Nkuo-Akenji, T. and Lindh, M. and Bergström, T.}},
  issn         = {{0950-2688}},
  keywords     = {{Enterovirus; epidemiology; Norwalk agent and related viruses; rotavirus; virus infection}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1393--1402}},
  publisher    = {{Cambridge University Press}},
  series       = {{Epidemiology and Infection}},
  title        = {{Monitoring of seasonality of norovirus and other enteric viruses in Cameroon by real-time PCR : An exploratory study}},
  url          = {{http://dx.doi.org/10.1017/S095026881300232X}},
  doi          = {{10.1017/S095026881300232X}},
  volume       = {{142}},
  year         = {{2014}},
}