An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment
(2021) In International Journal of Circumpolar Health 80(1).- Abstract
Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals. Thirty-one healthy subjects underwent whole-body exposures for 50 minutes on two occasions in an environmental chamber with intermittent moderate-intensity exercise in +10 °C and -10 °C. Lung function, plasma/urine CC16 , and symptoms were investigated before and after exposures. Compared to baseline, exercise in -10 °C decreased FEV1 (p=0.002), FEV1/FVC (p<0.001), and... (More)
Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals. Thirty-one healthy subjects underwent whole-body exposures for 50 minutes on two occasions in an environmental chamber with intermittent moderate-intensity exercise in +10 °C and -10 °C. Lung function, plasma/urine CC16 , and symptoms were investigated before and after exposures. Compared to baseline, exercise in -10 °C decreased FEV1 (p=0.002), FEV1/FVC (p<0.001), and increased R20Hz (p=0.016), with no differences between exposures. Reactance increased after +10 °C (p=0.005), which differed (p=0.042) from a blunted response after exercise in -10 °C. Plasma CC16 increased significantly within exposures, without differences between exposures. Exercise in -10 °C elicited more intense symptoms from the upper airways, compared to +10 °C. Symptoms from the lower airways were few and mild. Short-duration moderate-intensity exercise in -10 °C induces mild symptoms from the lower airways, no lung function decrements or enhanced leakage of biomarkers of airway epithelial injury, and no peripheral bronchodilatation, compared to exercise in +10 °C. .
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- author
- Eklund, Linda ; Schagatay, Filip ; Tufvesson, Ellen LU ; Sjöström, Rita ; Söderström, Lars ; Hanstock, Helen G. ; Sandström, Thomas and Stenfors, Nikolai
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- asthma, Cold temperature, environmental chamber, healthy, physical activity, respiratory symptoms
- in
- International Journal of Circumpolar Health
- volume
- 80
- issue
- 1
- article number
- 1897213
- publisher
- International Journal of Circumpolar Health
- external identifiers
-
- scopus:85102302227
- pmid:33685367
- ISSN
- 2242-3982
- DOI
- 10.1080/22423982.2021.1897213
- language
- English
- LU publication?
- yes
- id
- 4a62ebe5-cd1c-44bd-afc4-78305a5478a8
- date added to LUP
- 2021-03-29 13:30:36
- date last changed
- 2024-06-29 09:58:29
@article{4a62ebe5-cd1c-44bd-afc4-78305a5478a8,
abstract = {{<p>Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals. Thirty-one healthy subjects underwent whole-body exposures for 50 minutes on two occasions in an environmental chamber with intermittent moderate-intensity exercise in +10 °C and -10 °C. Lung function, plasma/urine CC16 , and symptoms were investigated before and after exposures. Compared to baseline, exercise in -10 °C decreased FEV<sub>1</sub> (p=0.002), FEV<sub>1</sub>/FVC (p<0.001), and increased R20Hz (p=0.016), with no differences between exposures. Reactance increased after +10 °C (p=0.005), which differed (p=0.042) from a blunted response after exercise in -10 °C. Plasma CC16 increased significantly within exposures, without differences between exposures. Exercise in -10 °C elicited more intense symptoms from the upper airways, compared to +10 °C. Symptoms from the lower airways were few and mild. Short-duration moderate-intensity exercise in -10 °C induces mild symptoms from the lower airways, no lung function decrements or enhanced leakage of biomarkers of airway epithelial injury, and no peripheral bronchodilatation, compared to exercise in +10 °C. .</p>}},
author = {{Eklund, Linda and Schagatay, Filip and Tufvesson, Ellen and Sjöström, Rita and Söderström, Lars and Hanstock, Helen G. and Sandström, Thomas and Stenfors, Nikolai}},
issn = {{2242-3982}},
keywords = {{asthma; Cold temperature; environmental chamber; healthy; physical activity; respiratory symptoms}},
language = {{eng}},
number = {{1}},
publisher = {{International Journal of Circumpolar Health}},
series = {{International Journal of Circumpolar Health}},
title = {{An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment}},
url = {{http://dx.doi.org/10.1080/22423982.2021.1897213}},
doi = {{10.1080/22423982.2021.1897213}},
volume = {{80}},
year = {{2021}},
}