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Autism spectrum disorders in the Stockholm Youth Cohort : design, prevalence and validity

Idring, Selma; Rai, Dheeraj; Dal, Henrik; Dalman, Christina; Sturm, Harald; Zander, Eric LU ; Lee, Brian K; Serlachius, Eva and Magnusson, Cecilia (2012) In PLoS ONE 7(7). p.41280-41280
Abstract

OBJECTIVE: Reports of rising prevalence of autism spectrum disorders (ASD), along with their profound personal and societal burden, emphasize the need of methodologically sound studies to explore their causes and consequences. We here present the design of a large intergenerational resource for ASD research, along with population-based prevalence estimates of ASD and their diagnostic validity.

METHOD: The Stockholm Youth Cohort is a record-linkage study comprising all individuals aged 0-17 years, ever resident in Stockholm County in 2001-2007 (N = 589,114). ASD cases (N = 5,100) were identified using a multisource approach, involving registers covering all pathways to ASD diagnosis and care, and categorized according to co-morbid... (More)

OBJECTIVE: Reports of rising prevalence of autism spectrum disorders (ASD), along with their profound personal and societal burden, emphasize the need of methodologically sound studies to explore their causes and consequences. We here present the design of a large intergenerational resource for ASD research, along with population-based prevalence estimates of ASD and their diagnostic validity.

METHOD: The Stockholm Youth Cohort is a record-linkage study comprising all individuals aged 0-17 years, ever resident in Stockholm County in 2001-2007 (N = 589,114). ASD cases (N = 5,100) were identified using a multisource approach, involving registers covering all pathways to ASD diagnosis and care, and categorized according to co-morbid intellectual disability. Prospectively recorded information on potential determinants and consequences of ASD were retrieved from national and regional health and administrative registers. Case ascertainment was validated through case-note review, and cross validation with co-existing cases in a national twin study.

RESULTS: The 2007 year prevalence of ASD in all children and young people was 11.5 per 1,000 (95% confidence interval 11.2-11.8), with a co-morbid intellectual disability recorded in 42.6% (41.0-44.2) of cases. We found 96.0% (92.0-98.4) of reviewed case-notes being consistent with a diagnosis of ASD, and confirmed ASD in 85.2% (66.2-95.8) of affected twins.

CONCLUSIONS: Findings from this contemporary study accords with recently reported prevalence estimates from Western countries at around 1%, based on valid case ascertainment. The Stockholm Youth Cohort, in light of the availability of extensive information from Sweden's registers, constitutes an important resource for ASD research. On-going work, including collection of biological samples, will enrich the study further.

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author
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Contribution to journal
publication status
published
subject
keywords
Adolescent, Child, Child Development Disorders, Pervasive/epidemiology, Child, Preschool, Cohort Studies, Female, Humans, Intellectual Disability/epidemiology, Male, Prevalence, Reproducibility of Results, Sweden, Young Adult
in
PLoS ONE
volume
7
issue
7
pages
41280 - 41280
publisher
Public Library of Science
external identifiers
  • scopus:84864085416
ISSN
1932-6203
DOI
10.1371/journal.pone.0041280
language
English
LU publication?
no
id
4ab9b980-540d-44ca-be12-fe387b733447
date added to LUP
2019-05-29 22:20:34
date last changed
2019-10-13 05:02:55
@article{4ab9b980-540d-44ca-be12-fe387b733447,
  abstract     = {<p>OBJECTIVE: Reports of rising prevalence of autism spectrum disorders (ASD), along with their profound personal and societal burden, emphasize the need of methodologically sound studies to explore their causes and consequences. We here present the design of a large intergenerational resource for ASD research, along with population-based prevalence estimates of ASD and their diagnostic validity.</p><p>METHOD: The Stockholm Youth Cohort is a record-linkage study comprising all individuals aged 0-17 years, ever resident in Stockholm County in 2001-2007 (N = 589,114). ASD cases (N = 5,100) were identified using a multisource approach, involving registers covering all pathways to ASD diagnosis and care, and categorized according to co-morbid intellectual disability. Prospectively recorded information on potential determinants and consequences of ASD were retrieved from national and regional health and administrative registers. Case ascertainment was validated through case-note review, and cross validation with co-existing cases in a national twin study.</p><p>RESULTS: The 2007 year prevalence of ASD in all children and young people was 11.5 per 1,000 (95% confidence interval 11.2-11.8), with a co-morbid intellectual disability recorded in 42.6% (41.0-44.2) of cases. We found 96.0% (92.0-98.4) of reviewed case-notes being consistent with a diagnosis of ASD, and confirmed ASD in 85.2% (66.2-95.8) of affected twins.</p><p>CONCLUSIONS: Findings from this contemporary study accords with recently reported prevalence estimates from Western countries at around 1%, based on valid case ascertainment. The Stockholm Youth Cohort, in light of the availability of extensive information from Sweden's registers, constitutes an important resource for ASD research. On-going work, including collection of biological samples, will enrich the study further.</p>},
  author       = {Idring, Selma and Rai, Dheeraj and Dal, Henrik and Dalman, Christina and Sturm, Harald and Zander, Eric and Lee, Brian K and Serlachius, Eva and Magnusson, Cecilia},
  issn         = {1932-6203},
  keyword      = {Adolescent,Child,Child Development Disorders, Pervasive/epidemiology,Child, Preschool,Cohort Studies,Female,Humans,Intellectual Disability/epidemiology,Male,Prevalence,Reproducibility of Results,Sweden,Young Adult},
  language     = {eng},
  number       = {7},
  pages        = {41280--41280},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Autism spectrum disorders in the Stockholm Youth Cohort : design, prevalence and validity},
  url          = {http://dx.doi.org/10.1371/journal.pone.0041280},
  volume       = {7},
  year         = {2012},
}