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Staphylococcus aureus induces release of bradykinin in human plasma

Mattsson, E. LU ; Herwald, H. LU orcid ; Cramer, H. ; Persson, K. LU ; Sjöbring, U. LU and Björck, L. LU (2001) In Infection and Immunity 69(6). p.3877-3882
Abstract

Staphylococcus aureus is a prominent human pathogen. Here we report that intact S. aureus bacteria activate the contact system in human plasma in vitro, resulting in a massive release of the potent proinflammatory and vasoactive peptide bradykinin. In contrast, no such effect was recorded with Streptococcus pneumoniae. In the activation of the contact system, blood coagulation factor XII and plasma kallikrein play central roles, and a specific inhibitor of these serine proteinases inhibited the release of bradykinin by S. aureus in human plasma. Furthermore, fragments of the cofactor H-kininogen of the contact system efficiently blocked bradykinin release. The results suggest that activation of the contact system at the surface of S.... (More)

Staphylococcus aureus is a prominent human pathogen. Here we report that intact S. aureus bacteria activate the contact system in human plasma in vitro, resulting in a massive release of the potent proinflammatory and vasoactive peptide bradykinin. In contrast, no such effect was recorded with Streptococcus pneumoniae. In the activation of the contact system, blood coagulation factor XII and plasma kallikrein play central roles, and a specific inhibitor of these serine proteinases inhibited the release of bradykinin by S. aureus in human plasma. Furthermore, fragments of the cofactor H-kininogen of the contact system efficiently blocked bradykinin release. The results suggest that activation of the contact system at the surface of S. aureus and the subsequent release of bradykinin could contribute to the hypovolemic hypotension seen in patients with severe S. aureus sepsis. The data also suggest that the contact system could be used as a target in the treatment of S. aureus infections.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
69
issue
6
pages
3877 - 3882
publisher
American Society for Microbiology
external identifiers
  • pmid:11349054
  • scopus:0035001194
ISSN
0019-9567
DOI
10.1128/IAI.69.6.3877-3882.2001
language
English
LU publication?
yes
id
4ad26762-eed3-4576-aed2-1f48523c064e
date added to LUP
2019-12-10 20:27:28
date last changed
2023-01-08 06:06:05
@article{4ad26762-eed3-4576-aed2-1f48523c064e,
  abstract     = {{<p>Staphylococcus aureus is a prominent human pathogen. Here we report that intact S. aureus bacteria activate the contact system in human plasma in vitro, resulting in a massive release of the potent proinflammatory and vasoactive peptide bradykinin. In contrast, no such effect was recorded with Streptococcus pneumoniae. In the activation of the contact system, blood coagulation factor XII and plasma kallikrein play central roles, and a specific inhibitor of these serine proteinases inhibited the release of bradykinin by S. aureus in human plasma. Furthermore, fragments of the cofactor H-kininogen of the contact system efficiently blocked bradykinin release. The results suggest that activation of the contact system at the surface of S. aureus and the subsequent release of bradykinin could contribute to the hypovolemic hypotension seen in patients with severe S. aureus sepsis. The data also suggest that the contact system could be used as a target in the treatment of S. aureus infections.</p>}},
  author       = {{Mattsson, E. and Herwald, H. and Cramer, H. and Persson, K. and Sjöbring, U. and Björck, L.}},
  issn         = {{0019-9567}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{3877--3882}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Infection and Immunity}},
  title        = {{Staphylococcus aureus induces release of bradykinin in human plasma}},
  url          = {{http://dx.doi.org/10.1128/IAI.69.6.3877-3882.2001}},
  doi          = {{10.1128/IAI.69.6.3877-3882.2001}},
  volume       = {{69}},
  year         = {{2001}},
}