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Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes.

Grip, Olof LU ; Janciauskiene, Sabina LU and Lindgren, Stefan LU (2002) In Inflammation Research 51(2). p.58-62
Abstract
OBJECTIVE: To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) in primary human monocytes in culture. MATERIALS AND METHODS: Human peripheral monocytes were incubated with atorvastatin (0.1-10 micromol/1) for up to 24 hours. PPAR-gamma expression was analysed by electrophoretic mobility shift assay. Pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assays, and oxygen consumption was determined polarographically with a Clark-type oxygen electrode. RESULTS: We found that atorvastatin activates PPAR-gamma and inhibits the production of tumour necrosis factor-alpha up to 38% (p < 0.05), monocyte chemoattractant protein-1 up to 85% (p <... (More)
OBJECTIVE: To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) in primary human monocytes in culture. MATERIALS AND METHODS: Human peripheral monocytes were incubated with atorvastatin (0.1-10 micromol/1) for up to 24 hours. PPAR-gamma expression was analysed by electrophoretic mobility shift assay. Pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assays, and oxygen consumption was determined polarographically with a Clark-type oxygen electrode. RESULTS: We found that atorvastatin activates PPAR-gamma and inhibits the production of tumour necrosis factor-alpha up to 38% (p < 0.05), monocyte chemoattractant protein-1 up to 85% (p < 0.05), and gelatinase B up to 73% (p < 0.05), in a concentration-dependent manner. Moreover, atorvastatin shows concentration-dependent inhibition of cellular oxygen consumption up to 41%. CONCLUSIONS: These findings contribute to the growing knowledge of the anti-inflammatory effects of statins, and have led us to the suggestion that statins may control inflammatory responses by the regulation of intracellular lipid homeostasis. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Inflammation Research
volume
51
issue
2
pages
58 - 62
publisher
Birkhäuser Verlag
external identifiers
  • pmid:11926313
  • wos:000174297500002
ISSN
1420-908X
language
English
LU publication?
yes
id
4ad5522a-38a6-4f0f-821e-75aeffe0acb3 (old id 107319)
alternative location
http://www.springerlink.com/openurl.asp?genre=article&issn=1023-3830&volume=51&issue=2&spage=58
date added to LUP
2016-04-01 11:58:48
date last changed
2018-11-21 20:02:26
@article{4ad5522a-38a6-4f0f-821e-75aeffe0acb3,
  abstract     = {{OBJECTIVE: To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) in primary human monocytes in culture. MATERIALS AND METHODS: Human peripheral monocytes were incubated with atorvastatin (0.1-10 micromol/1) for up to 24 hours. PPAR-gamma expression was analysed by electrophoretic mobility shift assay. Pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assays, and oxygen consumption was determined polarographically with a Clark-type oxygen electrode. RESULTS: We found that atorvastatin activates PPAR-gamma and inhibits the production of tumour necrosis factor-alpha up to 38% (p &lt; 0.05), monocyte chemoattractant protein-1 up to 85% (p &lt; 0.05), and gelatinase B up to 73% (p &lt; 0.05), in a concentration-dependent manner. Moreover, atorvastatin shows concentration-dependent inhibition of cellular oxygen consumption up to 41%. CONCLUSIONS: These findings contribute to the growing knowledge of the anti-inflammatory effects of statins, and have led us to the suggestion that statins may control inflammatory responses by the regulation of intracellular lipid homeostasis.}},
  author       = {{Grip, Olof and Janciauskiene, Sabina and Lindgren, Stefan}},
  issn         = {{1420-908X}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{58--62}},
  publisher    = {{Birkhäuser Verlag}},
  series       = {{Inflammation Research}},
  title        = {{Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes.}},
  url          = {{http://www.springerlink.com/openurl.asp?genre=article&issn=1023-3830&volume=51&issue=2&spage=58}},
  volume       = {{51}},
  year         = {{2002}},
}