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No association of salivary total tau concentration with Alzheimer's disease

Ashton, Nicholas J.; Ide, Mark; Schöll, Michael LU ; Blennow, Kaj LU ; Lovestone, Simon; Hye, Abdul and Zetterberg, Henrik LU (2018) In Neurobiology of Aging 70. p.125-127
Abstract

There is a need for an accessible biomarker that can complement current cerebrospinal fluid and imaging biomarkers in an accurate and early diagnosis of Alzheimer disease (AD). Saliva is a rich source of potential biomarkers and proteins related to neurodegenerative disorders have been shown to be present in this matrix, including tau. In this study, we quantified salivary total tau (t-tau) concentration in 160 healthy elderly control, 68 mild cognitive impairment, and 53 AD participants using ultrasensitive Single molecule array (Simoa) technology. No median difference in salivary t-tau concentration was found between AD and mild cognitive impairment or healthy elderly control (12.3 ng/L, 9.8 ng/L and 9.6 ng/L, respectively, p =... (More)

There is a need for an accessible biomarker that can complement current cerebrospinal fluid and imaging biomarkers in an accurate and early diagnosis of Alzheimer disease (AD). Saliva is a rich source of potential biomarkers and proteins related to neurodegenerative disorders have been shown to be present in this matrix, including tau. In this study, we quantified salivary total tau (t-tau) concentration in 160 healthy elderly control, 68 mild cognitive impairment, and 53 AD participants using ultrasensitive Single molecule array (Simoa) technology. No median difference in salivary t-tau concentration was found between AD and mild cognitive impairment or healthy elderly control (12.3 ng/L, 9.8 ng/L and 9.6 ng/L, respectively, p = 0.219). In addition, there was no association of salivary t-tau concentration with neurophysiological assessment or structural magnetic resonance imaging. Despite a nominal increase in AD, due to the large overlaps in concentrations between clinical groups, we conclude that salivary t-tau is a suitable biomarker neither for AD nor for cognitive impairment.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Biomarkers, Diagnosis, Fluid-biomarkers, Immunoassays, Saliva, Tau
in
Neurobiology of Aging
volume
70
pages
3 pages
publisher
Elsevier
external identifiers
  • scopus:85049512204
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2018.06.014
language
English
LU publication?
yes
id
4b0d6f39-044d-4f9f-8a85-593fa6a51b3b
date added to LUP
2018-07-20 09:23:36
date last changed
2019-10-15 06:42:00
@article{4b0d6f39-044d-4f9f-8a85-593fa6a51b3b,
  abstract     = {<p>There is a need for an accessible biomarker that can complement current cerebrospinal fluid and imaging biomarkers in an accurate and early diagnosis of Alzheimer disease (AD). Saliva is a rich source of potential biomarkers and proteins related to neurodegenerative disorders have been shown to be present in this matrix, including tau. In this study, we quantified salivary total tau (t-tau) concentration in 160 healthy elderly control, 68 mild cognitive impairment, and 53 AD participants using ultrasensitive Single molecule array (Simoa) technology. No median difference in salivary t-tau concentration was found between AD and mild cognitive impairment or healthy elderly control (12.3 ng/L, 9.8 ng/L and 9.6 ng/L, respectively, p = 0.219). In addition, there was no association of salivary t-tau concentration with neurophysiological assessment or structural magnetic resonance imaging. Despite a nominal increase in AD, due to the large overlaps in concentrations between clinical groups, we conclude that salivary t-tau is a suitable biomarker neither for AD nor for cognitive impairment.</p>},
  author       = {Ashton, Nicholas J. and Ide, Mark and Schöll, Michael and Blennow, Kaj and Lovestone, Simon and Hye, Abdul and Zetterberg, Henrik},
  issn         = {0197-4580},
  keyword      = {Alzheimer's disease,Biomarkers,Diagnosis,Fluid-biomarkers,Immunoassays,Saliva,Tau},
  language     = {eng},
  month        = {10},
  pages        = {125--127},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {No association of salivary total tau concentration with Alzheimer's disease},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.014},
  volume       = {70},
  year         = {2018},
}