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Fecal microbiota transplantation in obesity metabolism : A meta analysis and systematic review

Zecheng, Li ; Donghai, Liu ; Runchuan, Gu LU orcid ; Yuan, Qiao ; Qi, Jin ; Yijia, Zhang ; Shuaman, Ran ; Xiaoqi, Liu ; Yi, Wang and Ni, Mao , et al. (2023) In Diabetes Research and Clinical Practice 202.
Abstract

Objective: The effect of fecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome remains unclear. This systematic review employed a meta-analysis of RCTs for assessment on the role of FMT in treating obesity and metabolic syndrome, and its impact on clinically relevant parameters. Method: Major databases and grey literatures were searched identifying RCTs comparing FMT of lean donors with placebo in obese/metabolic syndrome patients. Studies using any form of placebo were included. Variations in the parameters before and after treatment were calculated followed by meta-analyses. Result: Ten studies met the inclusion criteria and a total of 334 patients were included for further analysis.... (More)

Objective: The effect of fecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome remains unclear. This systematic review employed a meta-analysis of RCTs for assessment on the role of FMT in treating obesity and metabolic syndrome, and its impact on clinically relevant parameters. Method: Major databases and grey literatures were searched identifying RCTs comparing FMT of lean donors with placebo in obese/metabolic syndrome patients. Studies using any form of placebo were included. Variations in the parameters before and after treatment were calculated followed by meta-analyses. Result: Ten studies met the inclusion criteria and a total of 334 patients were included for further analysis. Clinically significant parameters associated with obesity and metabolic syndrome were explored and FMT was identified significantly and negatively associated with most indices of abdominal adiposity including caloric intake, fasting glucose, HOMA-IR, systolic blood pressure, diastolic blood pressure, total cholesterol, HDL, LDL, triglycerides and CRP, Obesity parameters including fasting glucose and acetic acid were increased following FMT. Conclusion: FMT is more advantageous for obese patients with elevated blood pressure, disordered glucose and insulin metabolism, and elevated blood lipids. The study of metabolic factors in obese patients will be our starting point in the future.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fecal microbiota transplantation, Meta-analysis, Obesity
in
Diabetes Research and Clinical Practice
volume
202
article number
110803
publisher
Elsevier
external identifiers
  • pmid:37356723
  • scopus:85163865293
ISSN
0168-8227
DOI
10.1016/j.diabres.2023.110803
language
English
LU publication?
yes
id
4b11b748-7a27-4992-8538-2aaa746e23ae
date added to LUP
2023-09-06 15:08:27
date last changed
2024-02-20 00:53:55
@article{4b11b748-7a27-4992-8538-2aaa746e23ae,
  abstract     = {{<p>Objective: The effect of fecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome remains unclear. This systematic review employed a meta-analysis of RCTs for assessment on the role of FMT in treating obesity and metabolic syndrome, and its impact on clinically relevant parameters. Method: Major databases and grey literatures were searched identifying RCTs comparing FMT of lean donors with placebo in obese/metabolic syndrome patients. Studies using any form of placebo were included. Variations in the parameters before and after treatment were calculated followed by meta-analyses. Result: Ten studies met the inclusion criteria and a total of 334 patients were included for further analysis. Clinically significant parameters associated with obesity and metabolic syndrome were explored and FMT was identified significantly and negatively associated with most indices of abdominal adiposity including caloric intake, fasting glucose, HOMA-IR, systolic blood pressure, diastolic blood pressure, total cholesterol, HDL, LDL, triglycerides and CRP, Obesity parameters including fasting glucose and acetic acid were increased following FMT. Conclusion: FMT is more advantageous for obese patients with elevated blood pressure, disordered glucose and insulin metabolism, and elevated blood lipids. The study of metabolic factors in obese patients will be our starting point in the future.</p>}},
  author       = {{Zecheng, Li and Donghai, Liu and Runchuan, Gu and Yuan, Qiao and Qi, Jin and Yijia, Zhang and Shuaman, Ran and Xiaoqi, Liu and Yi, Wang and Ni, Mao and Yijin, Qin and Liang, Peng and Jun, Wang}},
  issn         = {{0168-8227}},
  keywords     = {{Fecal microbiota transplantation; Meta-analysis; Obesity}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Diabetes Research and Clinical Practice}},
  title        = {{Fecal microbiota transplantation in obesity metabolism : A meta analysis and systematic review}},
  url          = {{http://dx.doi.org/10.1016/j.diabres.2023.110803}},
  doi          = {{10.1016/j.diabres.2023.110803}},
  volume       = {{202}},
  year         = {{2023}},
}