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The Study Protocol for the LINC (LUCAS in Cardiac Arrest) Study : A study comparing conventional adult out-of-hospital cardiopulmonary resuscitation with a concept with mechanical chest compressions and simultaneous defibrillation

Rubertsson, Sten ; Silfverstolpe, Johan ; Rehn, Liselott ; Nyman, Thomas ; Lichtveld, Rob ; Boomars, Rene ; Bruins, Wendy ; Ahlstedt, Björn ; Puggioli, Helena and Lindgren, Erik , et al. (2013) In Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 21(1). p.1-9
Abstract

Background: The LUCAS™ device delivers mechanical chest compressions that have been shown in experimental studies to improve perfusion pressures to the brain and heart as well as augmenting cerebral blood flow and end tidal CO2, compared with results from standard manual cardiopulmonary resuscitation (CPR). Two randomised pilot studies in out-of-hospital cardiac arrest patients have not shown improved outcome when compared with manual CPR. There remains evidence from small case series that the device can be potentially beneficial compared with manual chest compressions in specific situations. This multicentre study is designed to evaluate the efficacy and safety of mechanical chest compressions with the LUCAS™ device whilst... (More)

Background: The LUCAS™ device delivers mechanical chest compressions that have been shown in experimental studies to improve perfusion pressures to the brain and heart as well as augmenting cerebral blood flow and end tidal CO2, compared with results from standard manual cardiopulmonary resuscitation (CPR). Two randomised pilot studies in out-of-hospital cardiac arrest patients have not shown improved outcome when compared with manual CPR. There remains evidence from small case series that the device can be potentially beneficial compared with manual chest compressions in specific situations. This multicentre study is designed to evaluate the efficacy and safety of mechanical chest compressions with the LUCAS™ device whilst allowing defibrillation during on-going CPR, and comparing the results with those of conventional resuscitation.Methods/design: This article describes the design and protocol of the LINC-study which is a randomised controlled multicentre study of 2500 out-of-hospital cardiac arrest patients. The study has been registered at ClinicalTrials.gov (http://clinicaltrials.gov/ct2/show/NCT00609778?term=LINC&rank=1). Results: Primary endpoint is four-hour survival after successful restoration of spontaneous circulation. The safety aspect is being evaluated by post mortem examinations in 300 patients that may reflect injuries from CPR.Conclusion: This large multicentre study will contribute to the evaluation of mechanical chest compression in CPR and specifically to the efficacy and safety of the LUCAS™ device when used in association with defibrillation during on-going CPR.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Asystole, Cardiac arrest, Defibrillation, External chest compressions, Mechanical chest compression, Pulseless electrical activity, Ventricular fibrillation
in
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
volume
21
issue
1
pages
9 pages
publisher
BioMed Central (BMC)
external identifiers
  • scopus:84872801994
  • pmid:23351178
ISSN
1757-7241
DOI
10.1186/1757-7241-21-5
language
English
LU publication?
no
id
4b23f220-dc8c-4ff6-bce7-224dfa7dd143
date added to LUP
2020-07-06 12:46:58
date last changed
2024-01-02 13:46:23
@article{4b23f220-dc8c-4ff6-bce7-224dfa7dd143,
  abstract     = {{<p>Background: The LUCAS™ device delivers mechanical chest compressions that have been shown in experimental studies to improve perfusion pressures to the brain and heart as well as augmenting cerebral blood flow and end tidal CO<sub>2,</sub> compared with results from standard manual cardiopulmonary resuscitation (CPR). Two randomised pilot studies in out-of-hospital cardiac arrest patients have not shown improved outcome when compared with manual CPR. There remains evidence from small case series that the device can be potentially beneficial compared with manual chest compressions in specific situations. This multicentre study is designed to evaluate the efficacy and safety of mechanical chest compressions with the LUCAS™ device whilst allowing defibrillation during on-going CPR, and comparing the results with those of conventional resuscitation.Methods/design: This article describes the design and protocol of the LINC-study which is a randomised controlled multicentre study of 2500 out-of-hospital cardiac arrest patients. The study has been registered at ClinicalTrials.gov (http://clinicaltrials.gov/ct2/show/NCT00609778?term=LINC&amp;rank=1). Results: Primary endpoint is four-hour survival after successful restoration of spontaneous circulation. The safety aspect is being evaluated by post mortem examinations in 300 patients that may reflect injuries from CPR.Conclusion: This large multicentre study will contribute to the evaluation of mechanical chest compression in CPR and specifically to the efficacy and safety of the LUCAS™ device when used in association with defibrillation during on-going CPR.</p>}},
  author       = {{Rubertsson, Sten and Silfverstolpe, Johan and Rehn, Liselott and Nyman, Thomas and Lichtveld, Rob and Boomars, Rene and Bruins, Wendy and Ahlstedt, Björn and Puggioli, Helena and Lindgren, Erik and Smekal, David and Skoog, Gunnar and Kastberg, Robert and Lindblad, Anna and Halliwell, David and Box, Martyn and Arnwald, Fredrik and Hardig, Bjarne Madsen and Chamberlain, Douglas and Herlitz, Johan and Karlsten, Rolf}},
  issn         = {{1757-7241}},
  keywords     = {{Asystole; Cardiac arrest; Defibrillation; External chest compressions; Mechanical chest compression; Pulseless electrical activity; Ventricular fibrillation}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{1--9}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine}},
  title        = {{The Study Protocol for the LINC (LUCAS in Cardiac Arrest) Study : A study comparing conventional adult out-of-hospital cardiopulmonary resuscitation with a concept with mechanical chest compressions and simultaneous defibrillation}},
  url          = {{http://dx.doi.org/10.1186/1757-7241-21-5}},
  doi          = {{10.1186/1757-7241-21-5}},
  volume       = {{21}},
  year         = {{2013}},
}