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Very Preterm Infants Auditory Event-Related Potentials at Term Have Low Predictive Value for Cognitive Outcome

Hövel, Holger Tingstedt ; Partanen, Eino ; Hansen Pupp, Ingrid LU orcid ; Ley, David LU ; Hüppi, Petra S. ; Rosén, Ingmar LU ; Månsson, Johanna LU ; Huotilainen, Minna and Fellman, Vineta LU orcid (2025) In Acta Paediatrica, International Journal of Paediatrics 114(9). p.2201-2210
Abstract

Aim: To assess the prognostic value of auditory event-related potentials (AERPs) registered at term equivalent age in very preterm infants. Methods: Infants (26.5 ± 2.0 gestational weeks (GWs), n = 41 of 64 recruited) were enrolled prenatally between January 2005 and May 2007 at Skåne University Hospital, Lund, Sweden. AERP and mismatch responses to changes in duration or frequency in pure tones were measured at term-equivalent age using EEG. Neurocognitive outcome was assessed at 2 years of corrected age with Bayley scales of infant development. At 12 years of age, the subgroup of children born before 27 GWs (n = 18) were assessed with Wechsler Intelligence Scale for Children Fifth Edition (WISC-V). Results: Larger negative AERP... (More)

Aim: To assess the prognostic value of auditory event-related potentials (AERPs) registered at term equivalent age in very preterm infants. Methods: Infants (26.5 ± 2.0 gestational weeks (GWs), n = 41 of 64 recruited) were enrolled prenatally between January 2005 and May 2007 at Skåne University Hospital, Lund, Sweden. AERP and mismatch responses to changes in duration or frequency in pure tones were measured at term-equivalent age using EEG. Neurocognitive outcome was assessed at 2 years of corrected age with Bayley scales of infant development. At 12 years of age, the subgroup of children born before 27 GWs (n = 18) were assessed with Wechsler Intelligence Scale for Children Fifth Edition (WISC-V). Results: Larger negative AERP amplitudes after 250 ms from stimulus onset to the standard and a negative rather than positive mismatch response to the frequency deviant were associated with higher Bayley score in univariable analysis. after adjustment for perinatal factors, only the duration mismatch response was associated with mental developmental index at 2 years of age. AERPs were not predictive of WISC-V test results at 12 years of age. Conclusion: AERPs at term in very preterm infants have a low prognostic value for short-term outcome. However, AERPs do not predict long-term outcome.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
child development, extremely preterm infant, mismatch response, neurocognition
in
Acta Paediatrica, International Journal of Paediatrics
volume
114
issue
9
pages
10 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:105004312172
  • pmid:40270127
ISSN
0803-5253
DOI
10.1111/apa.70089
language
English
LU publication?
yes
id
4b6d4c96-0afd-4542-9e9c-943289dd6261
date added to LUP
2025-09-16 15:57:38
date last changed
2025-10-28 20:32:40
@article{4b6d4c96-0afd-4542-9e9c-943289dd6261,
  abstract     = {{<p>Aim: To assess the prognostic value of auditory event-related potentials (AERPs) registered at term equivalent age in very preterm infants. Methods: Infants (26.5 ± 2.0 gestational weeks (GWs), n = 41 of 64 recruited) were enrolled prenatally between January 2005 and May 2007 at Skåne University Hospital, Lund, Sweden. AERP and mismatch responses to changes in duration or frequency in pure tones were measured at term-equivalent age using EEG. Neurocognitive outcome was assessed at 2 years of corrected age with Bayley scales of infant development. At 12 years of age, the subgroup of children born before 27 GWs (n = 18) were assessed with Wechsler Intelligence Scale for Children Fifth Edition (WISC-V). Results: Larger negative AERP amplitudes after 250 ms from stimulus onset to the standard and a negative rather than positive mismatch response to the frequency deviant were associated with higher Bayley score in univariable analysis. after adjustment for perinatal factors, only the duration mismatch response was associated with mental developmental index at 2 years of age. AERPs were not predictive of WISC-V test results at 12 years of age. Conclusion: AERPs at term in very preterm infants have a low prognostic value for short-term outcome. However, AERPs do not predict long-term outcome.</p>}},
  author       = {{Hövel, Holger Tingstedt and Partanen, Eino and Hansen Pupp, Ingrid and Ley, David and Hüppi, Petra S. and Rosén, Ingmar and Månsson, Johanna and Huotilainen, Minna and Fellman, Vineta}},
  issn         = {{0803-5253}},
  keywords     = {{child development; extremely preterm infant; mismatch response; neurocognition}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2201--2210}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{Very Preterm Infants Auditory Event-Related Potentials at Term Have Low Predictive Value for Cognitive Outcome}},
  url          = {{http://dx.doi.org/10.1111/apa.70089}},
  doi          = {{10.1111/apa.70089}},
  volume       = {{114}},
  year         = {{2025}},
}