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Arterial stiffness is associated with impaired orthostatic diastolic blood pressure reaction and increased central blood pressure: A prospective population‑based study

Johansson, Madeleine LU orcid ; Nilsson, Peter M LU ; Engström, Gunnar LU and Hamrefors, Viktor LU orcid (2021) ARTERY 21 Conference In Artery Research 27. p.5-6
Abstract
Background: Arterial stiffness is independently associated with orthostatic hypotension. We aimed to investigate the relationship between orthostatic blood pressure reaction and arterial stiffness as well as central hemodynamics in younger subjects from the general population.

Methods: We analyzed a large prospective cohort study of 3756 individuals from the general population (mean age 41.9±14.5 years, 52.1% women) in the Malmö Offspring Study (MOS), Sweden. Assessment of arterial stiffness and central hemodynamics was made by measurement of carotid-femoral pulse wave velocity (c-f PWV) (Sphygmocor® AtCor, Australia) and pulse wave analysis (PWA) at the
arteria radialis in relation to an orthostatic blood pressure reaction... (More)
Background: Arterial stiffness is independently associated with orthostatic hypotension. We aimed to investigate the relationship between orthostatic blood pressure reaction and arterial stiffness as well as central hemodynamics in younger subjects from the general population.

Methods: We analyzed a large prospective cohort study of 3756 individuals from the general population (mean age 41.9±14.5 years, 52.1% women) in the Malmö Offspring Study (MOS), Sweden. Assessment of arterial stiffness and central hemodynamics was made by measurement of carotid-femoral pulse wave velocity (c-f PWV) (Sphygmocor® AtCor, Australia) and pulse wave analysis (PWA) at the
arteria radialis in relation to an orthostatic blood pressure reaction after 5 min standing using linear regression models.

Results: We found a significant association between orthostatic diastolic blood pressure reaction and c-f PWV levels, that is, increased c-f PWV as observed in arterial stiffness, was associated with lower diastolic blood pressure increase upon standing after adjusting for age and sex (p=0.016). Moreover, we observed that increased systolic blood pressure on standing was associated with a higher central blood pressure in the ascending aorta after adjusting for age, sex, hemoglobin A1C (HbA1c) levels, and current smoking (p=0.006).

Conclusions: Our preliminary findings suggest that orthostatic hypotension, which is commonly observed in older individuals, is associated with markers of arterial stiffness (vascular ageing) and hemodynamic changes also in a younger population. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arterial stiffness, Vascular aging, Orthostatic blood pressure, Population Study
in
Artery Research
volume
27
pages
5 - 6
publisher
Elsevier
conference name
ARTERY 21 Conference
conference location
Paris, France
conference dates
2021-10-21 - 2021-10-23
external identifiers
  • pmid:34976230
ISSN
1872-9312
DOI
10.1007/s44200-021-00008-4
project
Vascular Ageing and Arterial Stiffness in the Swedish Population
language
English
LU publication?
yes
id
4ba1f69a-3d38-48df-842d-0d739bb9641d
date added to LUP
2022-02-23 13:29:02
date last changed
2022-12-07 14:15:48
@misc{4ba1f69a-3d38-48df-842d-0d739bb9641d,
  abstract     = {{Background: Arterial stiffness is independently associated with orthostatic hypotension. We aimed to investigate the relationship between orthostatic blood pressure reaction and arterial stiffness as well as central hemodynamics in younger subjects from the general population.<br/><br/>Methods: We analyzed a large prospective cohort study of 3756 individuals from the general population (mean age 41.9±14.5 years, 52.1% women) in the Malmö Offspring Study (MOS), Sweden. Assessment of arterial stiffness and central hemodynamics was made by measurement of carotid-femoral pulse wave velocity (c-f PWV) (Sphygmocor® AtCor, Australia) and pulse wave analysis (PWA) at the<br/>arteria radialis in relation to an orthostatic blood pressure reaction after 5 min standing using linear regression models.<br/><br/>Results: We found a significant association between orthostatic diastolic blood pressure reaction and c-f PWV levels, that is, increased c-f PWV as observed in arterial stiffness, was associated with lower diastolic blood pressure increase upon standing after adjusting for age and sex (p=0.016). Moreover, we observed that increased systolic blood pressure on standing was associated with a higher central blood pressure in the ascending aorta after adjusting for age, sex, hemoglobin A1C (HbA1c) levels, and current smoking (p=0.006).<br/><br/>Conclusions: Our preliminary findings suggest that orthostatic hypotension, which is commonly observed in older individuals, is associated with markers of arterial stiffness (vascular ageing) and hemodynamic changes also in a younger population.}},
  author       = {{Johansson, Madeleine and Nilsson, Peter M and Engström, Gunnar and Hamrefors, Viktor}},
  issn         = {{1872-9312}},
  keywords     = {{Arterial stiffness; Vascular aging; Orthostatic blood pressure; Population Study}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  pages        = {{5--6}},
  publisher    = {{Elsevier}},
  series       = {{Artery Research}},
  title        = {{Arterial stiffness is associated with impaired orthostatic diastolic blood pressure reaction and increased central blood pressure: A prospective population‑based study}},
  url          = {{http://dx.doi.org/10.1007/s44200-021-00008-4}},
  doi          = {{10.1007/s44200-021-00008-4}},
  volume       = {{27}},
  year         = {{2021}},
}