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Obesity and metabolic features associated with long-term developing diastolic dysfunction in an initially healthy population-based cohort

Chau, Kénora ; Girerd, Nicolas ; Magnusson, Martin LU orcid ; Lamiral, Zohra ; Bozec, Erwan ; Merckle, Ludovic ; Leosdottir, Margret LU ; Bachus, Erasmus LU ; Frikha, Zied and Ferreira, João Pedro , et al. (2018) In Clinical Research in Cardiology 107(10). p.887-896
Abstract

Background: Diastolic dysfunction (DD) is increasingly common. However, its metabolic determinants are poorly known. This study aims to determine which metabolic and inflammatory features predict DD in initially healthy adults. Methods: We prospectively analyzed the association between metabolic features and DD in 728 initially healthy adults aged 30–60 from Eastern France enrolled in the STANISLAS population-based cohort. Clinical and biological cardiovascular features were collected at baseline (1994–1995). DD was assessed twenty years later (2011–2016) by echocardiography using current international guidelines. For replication purposes, 1463 subjects from the Malmö Preventive Project cohort were analyzed. Results: In the STANISLAS... (More)

Background: Diastolic dysfunction (DD) is increasingly common. However, its metabolic determinants are poorly known. This study aims to determine which metabolic and inflammatory features predict DD in initially healthy adults. Methods: We prospectively analyzed the association between metabolic features and DD in 728 initially healthy adults aged 30–60 from Eastern France enrolled in the STANISLAS population-based cohort. Clinical and biological cardiovascular features were collected at baseline (1994–1995). DD was assessed twenty years later (2011–2016) by echocardiography using current international guidelines. For replication purposes, 1463 subjects from the Malmö Preventive Project cohort were analyzed. Results: In the STANISLAS cohort, 191 subjects (26.2%) developed DD. In age-sex-adjusted logistic models, significant predictors of DD were body mass index (BMI, odds ratio for 1-standard-deviation increase (OR) 1.28, 95% CI 1.08–1.52), waist circumference (WC, OR 1.48, 95% CI 1.18–1.84), waist-hip ratio (OR 1.53, 95% CI 1.16–2.02), systolic blood pressure (OR 1.19, 95% CI 1.00–1.43) and triglycerides (TG, OR 1.18, 95% CI 1.00–1.40). Subjects with elevated WC (> 80th percentile) and TG (> 50th percentile) had a twofold higher DD risk (age-sex-adjusted odds ratio 2.00, 95% CI 1.20–3.31, P = 0.008), whereas no such interplay was observed for BMI. In the Malmö cohort, BMI was similarly associated with DD; participants with both elevated BMI and TG were at higher DD risk (age-sex-adjusted odds ratio 1.61, 95% CI 1.18–2.20, P = 0.002). Conclusions: Subjects with elevated WC and TG may have a higher long-term DD risk. Prevention targeting visceral obesity may help reduce the incidence of DD.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood pressure, Cohort study, Diastolic dysfunction, Healthy adults, Triglycerides, Visceral fat
in
Clinical Research in Cardiology
volume
107
issue
10
pages
887 - 896
publisher
Steinkopff
external identifiers
  • pmid:29680861
  • scopus:85045770143
ISSN
1861-0684
DOI
10.1007/s00392-018-1259-6
language
English
LU publication?
yes
id
4bbd6d34-0df8-46e8-90db-04ebf679f6b7
date added to LUP
2018-05-02 14:34:29
date last changed
2024-04-01 05:10:41
@article{4bbd6d34-0df8-46e8-90db-04ebf679f6b7,
  abstract     = {{<p>Background: Diastolic dysfunction (DD) is increasingly common. However, its metabolic determinants are poorly known. This study aims to determine which metabolic and inflammatory features predict DD in initially healthy adults. Methods: We prospectively analyzed the association between metabolic features and DD in 728 initially healthy adults aged 30–60 from Eastern France enrolled in the STANISLAS population-based cohort. Clinical and biological cardiovascular features were collected at baseline (1994–1995). DD was assessed twenty years later (2011–2016) by echocardiography using current international guidelines. For replication purposes, 1463 subjects from the Malmö Preventive Project cohort were analyzed. Results: In the STANISLAS cohort, 191 subjects (26.2%) developed DD. In age-sex-adjusted logistic models, significant predictors of DD were body mass index (BMI, odds ratio for 1-standard-deviation increase (OR) 1.28, 95% CI 1.08–1.52), waist circumference (WC, OR 1.48, 95% CI 1.18–1.84), waist-hip ratio (OR 1.53, 95% CI 1.16–2.02), systolic blood pressure (OR 1.19, 95% CI 1.00–1.43) and triglycerides (TG, OR 1.18, 95% CI 1.00–1.40). Subjects with elevated WC (&gt; 80th percentile) and TG (&gt; 50th percentile) had a twofold higher DD risk (age-sex-adjusted odds ratio 2.00, 95% CI 1.20–3.31, P = 0.008), whereas no such interplay was observed for BMI. In the Malmö cohort, BMI was similarly associated with DD; participants with both elevated BMI and TG were at higher DD risk (age-sex-adjusted odds ratio 1.61, 95% CI 1.18–2.20, P = 0.002). Conclusions: Subjects with elevated WC and TG may have a higher long-term DD risk. Prevention targeting visceral obesity may help reduce the incidence of DD.</p>}},
  author       = {{Chau, Kénora and Girerd, Nicolas and Magnusson, Martin and Lamiral, Zohra and Bozec, Erwan and Merckle, Ludovic and Leosdottir, Margret and Bachus, Erasmus and Frikha, Zied and Ferreira, João Pedro and Després, Jean Pierre and Rossignol, Patrick and Boivin, Jean Marc and Zannad, Faiez}},
  issn         = {{1861-0684}},
  keywords     = {{Blood pressure; Cohort study; Diastolic dysfunction; Healthy adults; Triglycerides; Visceral fat}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{10}},
  pages        = {{887--896}},
  publisher    = {{Steinkopff}},
  series       = {{Clinical Research in Cardiology}},
  title        = {{Obesity and metabolic features associated with long-term developing diastolic dysfunction in an initially healthy population-based cohort}},
  url          = {{http://dx.doi.org/10.1007/s00392-018-1259-6}},
  doi          = {{10.1007/s00392-018-1259-6}},
  volume       = {{107}},
  year         = {{2018}},
}